Search Results

Overview

Uniprot IDA0A3B6ILN3
Protein NameHistone H2B
Gene NameLOC123090912
OrganismTriticum aestivum

Kla Sites from experimental identification

Position Flanking peptide
107 KLAGEAAKLARYNKK
13 EKKPAAKKPVEEEPA
23 EEEPAAEKAEKTPAG
26 PAAEKAEKTPAGKKP
43 EKRLPAGKSSAAAKE
60 KAKKKAKKSVETYKI

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein Sequence

10 MAPKAEKKPA 20 AKKPVEEEPA 30 AEKAEKTPAG 40 KKPKAEKRLP 50 AGKSSAAAKE 60 GGKAKKKAKK 70 SVETYKIYIF 80 KVLKQVHPDI 90 GISSKAMSIM 100 NSFINDIFEK 110 LAGEAAKLAR 120 YNKKPTITSR 130 EIQTSVRLVL 140 PGELAKHAVS 150 EGTKAVTKFT SS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0030527 structural constituent of chromatin
Biological Process GO:0006325 chromatin organization

Reference

[1] Zhu J, Guo W, Lan Y. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.. Int J Mol Sci 24(22). 2023 Nov 11. PMID: 38003390.