Search Results
Overview
| Uniprot ID | A0A3B6IPF3 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 2 subunit beta |
| Gene Name | LOC543269 |
| Organism | Triticum aestivum |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 29 | TKKKKKKKVVIQDPA |
Function
Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B
Protein Sequence
10
MADEEQMERK
20
EEATEIAPFD
30
PTKKKKKKKV
40
VIQDPADEVD
50
KLAEKTEGLS
60
VTESGEASFV
70
GLKKKKKKLV
80
ELDPSLVEAG
90
DGEDTLDDQV
100
GEDEQGEGIV
110
LGGATQYPWE
120
GTDRDYKYDE
130
LLGRVFNILR
140
ENNPDLAGDR
150
RRTVMRPPQV
160
LREGTKKTVF
170
VNFMDLCKTM
180
HRQPEHVMMF
190
LLAEMGTSGS
200
LDGQQRLVIK
210
GRFAPKNFEA
220
ILRRYINEYV
230
ICNGCKSPDT
240
ILSKENRLFF
250
LRCEQCGSSR
260
SVAPIKAGFV
270
AQVGRRKAGT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005850 | eukaryotic translation initiation factor 2 complex |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Molecular Function | GO:0031369 | translation initiation factor binding |
| Biological Process | GO:0001731 | formation of translation preinitiation complex |
Reference
[1] Zhu J, Guo W, Lan Y. Global Analysis of Lysine Lactylation of Germinated Seeds in Wheat.. Int J Mol Sci 24(22). 2023 Nov 11. PMID: 38003390.