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Overview

Uniprot ID	A0A480EKY5
Protein Name	Elongation factor G, mitochondrial
Gene Name	GFM1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
382	RNYQGELKKGDTIYN
523	GCPCITGKPKVAFRE

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRLLGAAAAA 20 AAVGRGPLPR 30 IPAALGWPGK 40 QANWKICRWC 50 SSGVIPNEKI 60 RNIGISAHID 70 SGKTTLTERV 80 LYYTGRIAKM 90 HEVKGKDGVG 100 AVMDSMELER 110 QRGITIQSAA 120 TYTLWKDVNI 130 NIIDTPGHVD 140 FTIEVERALR 150 VLDGAILVLC 160 AVGGVQCQTM 170 TVNRQMQRYS 180 VPFLTFINKL 190 DRMGSNPTRA 200 LQQMRSKLNH 210 NAALVQIPIG 220 LEGDFKGIID 230 LIEERAIYFD 240 GDFGQIVRYG 250 EIPAEFRAAA 260 SDHRQELIES 270 VANSDEQLGE 280 MFLEEKIPSA 290 SDLKLAIRRA 300 TINRSFTPVF 310 LGSALKNKGV 320 QPLLDAVVEY 330 LPNPSEVQNY 340 AILNQDDSQE 350 KTKILMNSKR 360 DDSHPFVGLA 370 FKLEAGRFGQ 380 LTYVRNYQGE 390 LKKGDTIYNT 400 RTRKKVRVQR 410 LVRMHADMME 420 DVEEVFAGDI 430 CALFGIDCAS 440 GDTFTNKENS 450 GLSMESIHVP 460 DPVISIAMKP 470 SNKNDLEKFS 480 KGIGRFTRED 490 PTFKVHFDTE 500 SKETIVSGMG 510 ELHLEIYAQR 520 MEREYGCPCI 530 TGKPKVAFRE 540 TITAPVPFEF 550 THKKQSGGAG 560 QFGKVIGVLE 570 PLDPENYTKL 580 EFSDETFGAN 590 VPKQFVPAVE 600 KGFLDACEKG 610 PLSGHKLSGL 620 RFVLQDGAHH 630 MVDSNEISFI 640 RAGEGALKQA 650 LANATVCILE 660 PIMSVEVIAP 670 NEFQGPVIAG 680 INRRHGVITG 690 QDGVEDYFTV 700 YAEVPLNDMF 710 GYSTELRSCT 720 EGKGEYTMEY 730 CRYQPCSPAT 740 QEDLVNKYLE 750 ATGQLPVKKG KAKN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0070125	mitochondrial translational elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.