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Overview

Uniprot IDA0A480F3K2
Protein NameProteasome activator complex subunit 1
Gene NamePSME1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
109 GPVNCNEKIVVLLQR
187 ERGDAVAKAAKQPHV
35 LLGSYFPKKISELDA

Function

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome

Protein Sequence

10 MATLRVQPEA 20 QAKVDVFRED 30 LCTKTENLLG 40 SYFPKKISEL 50 DAFLKEPALN 60 EANLSNLKAP 70 LDIPVPDPVK 80 EKEKEERKKQ 90 QEKEDKDEKK 100 KGEDEDKGPP 110 CGPVNCNEKI 120 VVLLQRLKPE 130 IKDVIEQLNL 140 VTTWLQLQIP 150 RIEDGNNFGV 160 AVQEKVFELM 170 TALHTKLEGF 180 HTQISKYFSE 190 RGDAVAKAAK 200 QPHVGDYRQL 210 VHELDEAEYR 220 DIRLMVMEIR 230 NAYAVLYDII 240 LKNFEKLKKP RGETKGMIY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008537 proteasome activator complex

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.