Search Results

Overview

Uniprot IDA0A480HZP7
Protein NameProtein flightless-1 homolog
Gene NameFLII
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1007 FTFSLQKKFESLFPG
1173 LFRCSNEKGYFAVTE
1222 VEIKLSLKACQVYIQ
558 GEATLDKKACSAIHA
631 VYGKKNIKLEPVPLK
671 ATLSSTTKARLFAEK
832 GTEAQVFKAKFKNWD

Function

Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments. It also plays a role in the assembly of cardiomyocyte cell adhesion complexes. Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling

Protein Sequence

10 MEATGVLPFV 20 RGVDLSGNDF 30 KGGYFPENVK 40 AMTSLRWLKL 50 NRTGLCYLPE 60 ELAALQKLEH 70 LSVSHNHLTT 80 LHGDLSSLPS 90 LRAIVARANS 100 LKNSGVPDDI 110 FKLDDLSVLD 120 LSYNQLTECP 130 RELENAKNML 140 VLNLSHNSIE 150 SIPNQLFINL 160 TDLLYLDLGE 170 NRLESLPPQM 180 RRLVHLQTLV 190 LNGNPLLHAQ 200 LRQLPALTAL 210 QTLHLRNTQR 220 TQSNLPTSLE 230 GLSNLADVDL 240 SCNDLTRVPE 250 CLYTLPSLRR 260 LNLSSNQITE 270 LSLCIDQWVH 280 VETLNLSRNQ 290 LTSLPSAICK 300 LTKLKRLYLN 310 SNKLDFDGLP 320 SGIGKLASLE 330 EFMAANNNLE 340 LIPESLCRCT 350 KLRKLVLNKN 360 RLVTLPEAVH 370 FLTEIEVLDV 380 RENPSLVMPP 390 KPADRAAEWY 400 NIDFSLQNQL 410 RLAGASPATV 420 AAAAAAGSGP 430 KDPLARKMRL 440 RRRKDSAQDD 450 QAKQVLKGMS 460 DVAQEKNRKQ 470 EEGADARAPG 480 AKVRRWDQGL 490 EKPRLDYSEF 500 FTEDVGQLPG 510 LTIWQIENFV 520 PVLVEEALHG 530 KFYEADCYIV 540 LKTFLDDSGS 550 LSWAIYYWIG 560 GEATLDKKAC 570 SAIHAVNLRN 580 YLGAECRTVR 590 EEMGDESEEF 600 LQVFDSDISY 610 VEGGTASGFY 620 TVEDTHYVTR 630 MYRVYGKKNI 640 KLEPVPLKGA 650 SLDPRFVFLL 660 DRGLDIDVWR 670 GAQATLSSTT 680 KARLFAEKIN 690 KNERKGKAEI 700 SLLVQGQEPP 710 EFWEVLGGEP 720 AEIKKHVPDD 730 FWPPQPKLYK 740 VGLGLGYLEL 750 PQINYKLSVE 760 HKTRPKVELM 770 PRMRLLQSLL 780 DTRCVYILDC 790 WSDVFIWLGR 800 KSPRLVRAAA 810 LKLGQELCGM 820 LHRPRHATVS 830 RSLEGTEAQV 840 FKAKFKNWDD 850 VLTVDYTRNA 860 EAVLQGPGLA 870 GKVKRDAEKK 880 DQMKADLTAL 890 FLPRQPPMAL 900 AEAEQLMEEW 910 NEDLDGMEGF 920 VLEGKKFARL 930 PEEEFGHFYT 940 QDCYVFLCRY 950 WVPVEYEEEE 960 ERKEENEDEK 970 AGAEGEDGEA 980 AAAKQPEEDF 990 QCVVYFWQGR 1000 EASTMGWLTF 1010 TFSLQKKFES 1020 LFPGKLEVVR 1030 MTQQQENPKF 1040 LSHFKRKFVI 1050 HRGRRRAAQG 1060 APQPSLYQIR 1070 TNGSALCTRC 1080 IQINTDSGLL 1090 NSEFCFILKV 1100 PFESEDNQGI 1110 VYAWVGRASD 1120 PDEAKLAEDI 1130 LNSMFEASYS 1140 KQVINEGEEP 1150 ENFFWVGIGA 1160 QKPYDDDAEY 1170 MKHTRLFRCS 1180 NEKGYFAVTE 1190 KCSDFCQDDL 1200 ADDDIMLLDN 1210 GQEVYMWVGT 1220 QTSQVEIKLS 1230 LKACQVYIQH 1240 LRSKEHERPR 1250 RLRLVRKGNE 1260 QHAFTRCFHA WSTFRKALA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005903 brush border
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0002102 podosome
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process GO:0051014 actin filament severing
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030239 myofibril assembly
Biological Process GO:0045214 sarcomere organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.