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Overview

Uniprot IDA0A480J3V8
Protein NameKeratin, type I cytoskeletal 19
Gene NameKRT19
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
101 RLASYLEKVRALEQA

Function

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle

Protein Sequence

10 MTSYSYRQSS 20 ATSSFGGLGG 30 GSVRFSAGGA 40 FRAPSIHGGS 50 GGRGVSVSSA 60 RFVSSSSSGG 70 YGGGYGGGYA 80 GALAGSDGLL 90 AGNEKLTMQN 100 LNDRLASYLE 110 KVRALEQANG 120 DLEVKIRDWY 130 QKQGPGPARD 140 YSHYFKTIED 150 LRDKILGATI 160 ENSKIVLQID 170 NARLAADDFR 180 TKFETEQALR 190 LSVEADINGL 200 RRVLDELTLA 210 RTDLELQIEG 220 LKEELAYLKK 230 NHEEEISALK 240 GQVGGQVSVE 250 VDSAPGIDLA 260 KILSDMRSQY 270 EVMAEQNRKD 280 AEAWFTSRTE 290 ELNREVAGHT 300 EQLQISKTEV 310 TDLRRTLQGL 320 EIELQSQLSM 330 KAALEGTLAE 340 TEARFGAQLA 350 QIQALISGIE 360 AQLSDVRADT 370 ERQNQEYQHL 380 MDIKTRLEQE 390 IATYRNLLEG 400 QDANYNNLTI IKAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0043034 costamere
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0045095 keratin filament
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:1990357 terminal web
Cellular Component GO:0030018 Z disc
Molecular Function GO:0008307 structural constituent of muscle
Molecular Function GO:0030280 structural constituent of skin epidermis
Biological Process GO:0030855 epithelial cell differentiation
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0002009 morphogenesis of an epithelium
Biological Process GO:0043627 response to estrogen
Biological Process GO:0045214 sarcomere organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.