Search Results

Overview

Uniprot IDA0A480JYQ8
Protein NameWings apart-like protein homolog
Gene NameWAPL
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
27 FDEVFSNKRTTLSTK
308 YCRANKAKSSQGASS
344 DGLNQAKKGSVSCGT
413 KADIATSKTTTRFRP
547 KSKENTRKIFSGPKR
553 RKIFSGPKRSPTKAV
597 SSKEQNQKDDGVFKA
610 KAPAPPPKVIKTVTI

Function

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair

Protein Sequence

10 MTSRFGKTYS 20 RKGGNGSSKF 30 DEVFSNKRTT 40 LSTKWGETTF 50 MAKLGQKRPN 60 FKPDIQEVPK 70 KPKMEEENTG 80 DPFGFDSDDE 90 SLPVSSKNLA 100 QGKGSSYSES 110 SEAAQLEDVT 120 SVLEANSKIS 130 QVMGEDSVVS 140 DKCLRLEDTL 150 LGKEKSTNRV 160 LEDGASRSSC 170 AKLMTSDKVE 180 SFSEEHEKNS 190 HHIYKNAEDS 200 TKKPSAETTV 210 ASGYRADEIK 220 ETNDTWNSQH 230 GKRSESPSET 240 SPIKGSIRTG 250 LYEWDNDFED 260 IRSEDCVLSL 270 DSGPVLEMKD 280 EDLKNRLENL 290 NEAIEEDIMQ 300 SVLRPSNCRT 310 YCRANKAKSS 320 QGASSFDKLM 330 DGTSQASAKA 340 NSESSKDGLN 350 QAKKGSVSCG 360 TSFRGTVGRT 370 RDYTVLHPSC 380 LSVCNVTIQD 390 TMERSMDEFT 400 ASTPADLGEA 410 GRLRKKADIA 420 TSKTTTRFRP 430 SNTKSKKDVK 440 LEFFGFEDHD 450 DTGGDEGGSG 460 SSNYKIKYFG 470 FDDLSESEDD 480 EDDDCQVERK 490 TSKKRTKTAP 500 SPSLQPPPES 510 NDNSQDSQSS 520 TNNAENLDFT 530 EDLPGVPESV 540 KKPPNKQGDK 550 SKENTRKIFS 560 GPKRSPTKAV 570 YNARHWNHPD 580 SEELPGPPVA 590 KPQSVPVRLS 600 SKEQNQKDDG 610 VFKAPAPPPK 620 VIKTVTIPTQ 630 PYQDIVTALK 640 CRKEDKELYT 650 VVQHVKHFND 660 VVEFGENQEF 670 TDDIEYLLSG 680 LKSTQPLNTR 690 CLSVISLATK 700 CAMPSFRMHL 710 RAHGMVAMVF 720 KTLDDSQHHQ 730 NLSLCTAALM 740 YILSRDRLNM 750 DLDRASLDLM 760 IRLLELEQDA 770 SSAKLLNEKD 780 MNKIKEKIRR 790 LCETVHNKHL 800 DLENITTGHL 810 AMETLLSLTS 820 KRAGDWFKEE 830 LRLLGGLDHI 840 VDKVKECVDH 850 LSRDEDEEKL 860 VASLWGAERC 870 LRVLESVTVH 880 NPENQSYLIA 890 YKDSQLIVSS 900 AKALQHCEEL 910 IKQYNRAENS 920 ICLPDSKPLP 930 HQNVTNHVGK 940 AVEDCMRAII 950 GVLLNLTNDN 960 EWGSTKTGEQ 970 DGLIGTAMNC 980 VLQVPKYLPQ 990 EQRFDIRVLG 1000 LGLLINLVEY 1010 SARNRHCLVN 1020 METSCSFDSS 1030 FCSGEGDDSL 1040 RIAGQVHAVQ 1050 ALVQLFLERE 1060 RAAQLAESKT 1070 DELIKDAPTT 1080 QHDKSGEWQE 1090 TSGEIQWVAT 1100 EKTDGTEEKH 1110 KKEEDDEELD 1120 LNKALQHAGK 1130 HMEDCIVASY 1140 TALLLGCLCQ 1150 ESPINVTTVR 1160 EYLPEGDFSI 1170 MTEMLKKFLS 1180 FMNLTCAVGT 1190 TGQKSISRVI EYLEHC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0042585 germinal vesicle
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0000795 synaptonemal complex
Molecular Function GO:0140083 ATP-dependent protein-DNA unloader activity
Biological Process GO:0051301 cell division
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0008156 negative regulation of DNA replication
Biological Process GO:0045875 negative regulation of sister chromatid cohesion
Biological Process GO:0071168 protein localization to chromatin

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.