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Overview

Uniprot ID	A0A480KYP4
Protein Name	Nuclear factor of activated T-cells, cytoplasmic 1
Gene Name	NFATC2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
453	QVHRITGKTVTTTSY

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function

Protein Sequence

10 MQREAAFRLG 20 HCQPLRIMGS 30 VDQEEPNAHK 40 VASPPSGPDD 50 VLDYGLKPYS 60 PLASLSGEPP 70 GRLGEPDRVG 80 PQSFLSPAKP 90 AGASGLSPRI 100 EITPSHELIQ 110 AGGPFRVRDT 120 GLLVEQPPPP 130 GVAASPRFTL 140 PVPGFEGYRE 150 PLCLSPASSG 160 SSASFISDTF 170 SPYTSPCVSP 180 NNGGPDDLCP 190 QFQNIPAHYS 200 PRTSPIMSPR 210 TGLAEDSCLG 220 RHSPVPRPAS 230 RSSSPGAKRR 240 HSCAGALVAP 250 LPGASPQRSR 260 SPSPQPRDDG 270 APAGYPPAAG 280 SAVLMDALNS 290 LAADSSCGIP 300 PKMWKTSPDP 310 SPVSAAPPKA 320 GLPRHIYPAV 330 EFLGPCEQEE 340 RRNSAPESIL 350 LVPPTWPKQL 360 VPAIPICSIP 370 VTASLPPLEW 380 PLSHQSGSYE 390 LRIEVQPKPH 400 HRAHYETEGS 410 RGAVKAPTGG 420 HPVVQLHGYM 430 ENKPLGLQIF 440 IGTADERILK 450 PHAFYQVHRI 460 TGKTVTTTSY 470 EKIVGNTKVL 480 EIPLEPKNNM 490 RATIDCAGIL 500 KLRNADIELR 510 KGETDIGRKN 520 TRVRLVFRVH 530 IPEASGRIIS 540 LQTASNPIEC 550 SQRSAHELPM 560 VERQDIDSCL 570 VYGGQQMILT 580 GQNFTAESKV 590 VFTEKTTDGQ 600 QIWEMEATVD 610 KDKSQPNMLF 620 VEIPEYRNKH 630 IRASVKVNFY 640 VINGKRKRSQ 650 PQHFTYHPVP 660 AIKTEPTDEY 670 DPTLICSPAH 680 GGLGSQPYYP 690 QHPMVAESPS 700 CLVATMAPCQ 710 QFRSGLSSPD 720 ARYQQQNPAA 730 VLYQRSKSLS 740 PSLLGYQQPA 750 LMATPLALAD 760 AHRSVLVHTG 770 SQGQSSALLH 780 SGPANQQASP 790 VIHYSPTNQQ 800 LRCGSHQEFQ 810 HIMYCENFAP 820 GTTRPGPPPV 830 SQGQRLSPGS 840 YPTVIQQQNA 850 TNQRAAKNGP 860 PVSDQKEVLP 870 SGVTIKQEQN 880 LDQTYLDDEL 890 IDTHLSWIQN IL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003700	DNA-binding transcription factor activity
Biological Process	GO:0006351	DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.