Search Results
Overview
| Uniprot ID | A0A480LAQ9 |
|---|---|
| Protein Name | Core histone macro-H2A |
| Gene Name | MACROH2A1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | IITPPPAKKAKSPSQ |
| 18 | TKTSRSAKAGVIFPV |
| 285 | SPVWGADKCEELLEK |
| 295 | ELLEKTVKNCLALAD |
| 304 | CLALADDKKLKSIAF |
| 307 | LADDKKLKSIAFPSI |
Function
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes
Protein Sequence
10
MSSRGGKKKS
20
TKTSRSAKAG
30
VIFPVGRMLR
40
YIKKGHPKYR
50
IGVGAPVYMA
60
AVLEYLTAEI
70
LELAGNAARD
80
NKKGRVTPRH
90
ILLAVANDEE
100
LNQLLKGVTI
110
ASGGVLPNIH
120
PELLAKKRGS
130
KGKLEAIITP
140
PPAKKAKSPS
150
QKKPVSKKTG
160
GKKGARKSKK
170
KQGEVSKAAS
180
ADSTTEGTPA
190
DGFTVLSTKS
200
LFLGQKLNLI
210
HSEISNLAGF
220
EVEAIINPTN
230
ADIDLKDDLG
240
NTLEKKGGKE
250
FVEAVLELRK
260
KNGPLEVAGA
270
AVSAGHGLPA
280
KFVIHCNSPV
290
WGADKCEELL
300
EKTVKNCLAL
310
ADDKKLKSIA
320
FPSIGSGRNG
330
FPKQTAAQLI
340
LRAISSYFVS
350
TMSSSIKTVY
360
FVLFDSESIG
370
IYVQEMAKLD
AN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0001740 | Barr body |
| Cellular Component | GO:0000793 | condensed chromosome |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Cellular Component | GO:0090734 | site of DNA damage |
| Molecular Function | GO:0160002 | ADP-D-ribose modification-dependent protein binding |
| Molecular Function | GO:0010385 | double-stranded methylated DNA binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| Molecular Function | GO:0000182 | rDNA binding |
| Molecular Function | GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0071169 | establishment of protein localization to chromatin |
| Biological Process | GO:1902750 | negative regulation of cell cycle G2/M phase transition |
| Biological Process | GO:0045814 | negative regulation of gene expression, epigenetic |
| Biological Process | GO:1904815 | negative regulation of protein localization to chromosome, telomeric region |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1901837 | negative regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| Biological Process | GO:0006334 | nucleosome assembly |
| Biological Process | GO:1903226 | positive regulation of endodermal cell differentiation |
| Biological Process | GO:0045618 | positive regulation of keratinocyte differentiation |
| Biological Process | GO:0034184 | positive regulation of maintenance of mitotic sister chromatid cohesion |
| Biological Process | GO:0019216 | regulation of lipid metabolic process |
| Biological Process | GO:1902688 | regulation of NAD metabolic process |
| Biological Process | GO:0002082 | regulation of oxidative phosphorylation |
| Biological Process | GO:1902882 | regulation of response to oxidative stress |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.