Overview
| Uniprot ID | A0A480LI92 |
|---|
| Protein Name | EARP and GARP complex-interacting protein 1 |
|---|
| Gene Name | EIPR1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 226 |
CGDDCRVKFWDTRKV |
| 58 |
VLATCYNKTADSKVL |
Function
Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes
Protein Sequence
10
MEDDAPVIYG
20
LEFQIHIIDF
30
DDENNIINKN
40
VLLHRAGEIW
50
HISASPADKG
60
VLATCYNKTA
70
DSKVLTCAAV
80
WRMPAELEPG
90
GHESPEDAAS
100
PAHALELLCH
110
LDHPARGSTA
120
CVAWEPAGDG
130
KRVISLADNH
140
LLLWDLQESS
150
SQALLASSAS
160
LEGKGQLKFT
170
TGRWSPHHSC
180
TQVATANDTA
190
VRGWDTRTMS
200
QIYCIENAHG
210
QLVRDLDFNP
220
NKQYCLASCG
230
DDCRVKFWDT
240
RKVTEPVRTL
250
EEHSHWVWNV
260
RYNHSHDQLV
270
LTASSDSRVI
280
LSNMASISSE
290
PFGHLVDDDD
300
LSDQEERRPE
310
EKSQEPPQDS
320
VIATYEEHED
330
SVYAVEWAAA
340
DPWLFASLSY
350
DGRLVVNRVP
RALKYRILL
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0051049 |
regulation of transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.