Search Results

Overview

Uniprot IDA0A480LMF4
Protein NameTyrosine-protein phosphatase non-receptor type
Gene NamePTPN11
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
178 MIRCQELKYDVGGGE
280 NKNKNRYKNILPFDH
405 LRELKLSKVGQGNTE
482 LIDIIREKGVDCDID

Function

No function data available.

Protein Sequence

10 MTSRRWFHPN 20 ITGVEAENLL 30 LTRGVDGSFL 40 ARPSKSNPGD 50 FTLSVRRNGA 60 VTHIKIQNTG 70 DYYDLYGGEK 80 FATLAELVQY 90 YMEHHGQLKE 100 KNGDVIELKY 110 PLNCADPTSE 120 RWFHGHLSGK 130 EAEKLLTEKG 140 KHGSFLVRES 150 QSHPGDFVLS 160 VRTGDDKGES 170 NDGKSKVTHV 180 MIRCQELKYD 190 VGGGERFDSL 200 TDLVEHYKKN 210 PMVETLGTVL 220 QLKQPLNTTR 230 INAAEIESRV 240 RELSKLAETT 250 DKVKQGFWEE 260 FETLQQQECK 270 LLYSRKEGQR 280 QENKNKNRYK 290 NILPFDHTRV 300 VLHDGDPNEP 310 VSDYINANII 320 MPEFETKCNN 330 SKPKKSYIAT 340 QGCLQNTVND 350 FWRMVFQENS 360 RVIVMTTKEV 370 ERGKSKCVKY 380 WPDEYALKEY 390 GVMRVRNVKE 400 SAAHDYTLRE 410 LKLSKVGQGN 420 TERTVWQYHF 430 RTWPDHGVPS 440 DPGGVLDFLE 450 EVHHKQESIM 460 DAGPVVVHCS 470 AGIGRTGTFI 480 VIDILIDIIR 490 EKGVDCDIDV 500 PKTIQMVRSQ 510 RSGMVQTEAQ 520 YRFIYMAVQH 530 YIETLQRRIE 540 EEQKSKRKGH 550 EYTNIKYSLT 560 DQAGGEQSPL 570 PPCTPTPSCA 580 EMREDNARVY 590 ENVGLMQQQK SFR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Biological Process GO:0007420 brain development
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0038127 ERBB signaling pathway
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0048806 genitalia development
Biological Process GO:0048839 inner ear development
Biological Process GO:0033629 negative regulation of cell adhesion mediated by integrin
Biological Process GO:0032331 negative regulation of chondrocyte differentiation
Biological Process GO:1902564 negative regulation of neutrophil activation
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0050860 negative regulation of T cell receptor signaling pathway
Biological Process GO:0032480 negative regulation of type I interferon production
Biological Process GO:0046326 positive regulation of D-glucose import across plasma membrane
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0046628 positive regulation of insulin receptor signaling pathway
Biological Process GO:0032728 positive regulation of interferon-beta production
Biological Process GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
Biological Process GO:0045778 positive regulation of ossification
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0032760 positive regulation of tumor necrosis factor production
Biological Process GO:0043254 regulation of protein-containing complex assembly
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0050839 cell adhesion molecule binding
Molecular Function GO:0005158 insulin receptor binding
Molecular Function GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Molecular Function GO:0051428 peptide hormone receptor binding
Molecular Function GO:0001784 phosphotyrosine residue binding
Molecular Function GO:0030971 receptor tyrosine kinase binding
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Biological Process GO:0036302 atrioventricular canal development

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.