Search Results
Overview
| Uniprot ID | A0A480M584 |
|---|---|
| Protein Name | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 |
| Gene Name | PLOD1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 76 | ASSGGGLKVRLLKKA |
Function
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Protein Sequence
10
MRLLLLLAPL
20
GWLLLTETKG
30
DAKPEDNLLV
40
LTVATKETEG
50
FRRFKRSAQF
60
FNYKIQALGL
70
GEDWNEKEAS
80
SGGGLKVRLL
90
KKALEKHADE
100
NLVILFTDSY
110
DVVFASGPRE
120
LLKKFRQAKS
130
QVVFSAEELI
140
YPDRRLEAKY
150
PAVSDGKRFL
160
GSGGFIGYAP
170
NLSKLVAEWE
180
GQDSDSDQLF
190
YTKIFLDPEK
200
RERINITLDH
210
RCRIFQNLDG
220
ALDEVVLKFE
230
MGQVRARNLA
240
YDTLPVLIHG
250
NGPTKLQLNY
260
LGNYIPRFWT
270
FETGCSVCDE
280
GLRSLKGIGD
290
EALPTVLVGL
300
FIEQPTPFLS
310
LFFQRLLRLQ
320
YPRKRMRLFI
330
HNHEQHHKAL
340
VEQFLAEHGD
350
EYQSVKLVGP
360
EVRVANADAR
370
NMGADLCRQD
380
RSCTYYFSVD
390
ADVALTEPKT
400
LRLLIEQNKN
410
VLAPLMTRHG
420
RLWSNFWGAL
430
SADGYYARSE
440
DYVDIVQGRR
450
VGVWNVPYIS
460
NVYLIKGSAL
470
RAELQQTDLF
480
HHSKLDPDMA
490
FCANIRQQDV
500
FMFLTNRHAF
510
GHLLSLDSYQ
520
TTHLHNDLWE
530
VFSNPEDWKE
540
KYIHENYTKA
550
LAGKLVETPC
560
PDVYWFPIFT
570
ETACDELVEE
580
MEHYGQWSLG
590
DNKDNRIQGG
600
YENVPTIDIH
610
MNQISFEREW
620
HKFLVEYIAP
630
MTEKLYPGYY
640
TRAQFDLAFV
650
VRYKPDEQPS
660
LMPHHDASTF
670
TINIALNRVG
680
VDYEGGGCRF
690
LRYNCSIRAP
700
RKGWTLMHPG
710
RLTHYHEGLP
720
TTKGTRYIAV
SFVDP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030867 | rough endoplasmic reticulum membrane |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0031418 | L-ascorbic acid binding |
| Molecular Function | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
| Biological Process | GO:0030199 | collagen fibril organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.