Search Results
Overview
| Uniprot ID | A0A480MCK3 |
|---|---|
| Protein Name | AKT-interacting protein |
| Gene Name | AKTIP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 218 | SKVVDSVKVCTARLF |
Function
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell
Protein Sequence
10
MNPFWSMSTS
20
SVRKRSDGEE
30
KTLTGDVKSS
40
PPRTAPKKQL
50
PSIPKNALPI
60
TKPTSPAPAT
70
QSTNGTHASY
80
GPFYLEYSLL
90
AEFTLVVKQK
100
LPGVYVQPSY
110
RSALMWFGVI
120
FIRHGLYQDG
130
VFKFTVYIPD
140
NYPDGDCPRL
150
VFDIPVFHPL
160
VDPNSGELDV
170
KRAFAKWRRN
180
HNHIWQVLMY
190
ARRVFYKIDT
200
ANPLNPEAAV
210
LYEKDVQLFK
220
SKVVDSVKVC
230
TARLFDQPKI
240
EDPYAISFSP
250
WNPSVHDEAR
260
EKMLTQKKPE
270
EQHNKSVHVA
280
GLSWVKPGSV
290
QPFSKEEKTV
AT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070695 | FHF complex |
| Cellular Component | GO:0030897 | HOPS complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0006301 | DNA damage tolerance |
| Biological Process | GO:0045022 | early endosome to late endosome transport |
| Biological Process | GO:0007032 | endosome organization |
| Biological Process | GO:0008333 | endosome to lysosome transport |
| Biological Process | GO:0007040 | lysosome organization |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:1905719 | protein localization to perinuclear region of cytoplasm |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.