Search Results
Overview
| Uniprot ID | A0A480NRZ3 |
|---|---|
| Protein Name | Prelamin-A/C |
| Gene Name | LMNA |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | RLQLELSKVREEFKE |
| 114 | SKVREEFKELKARNT |
| 123 | LKARNTKKEGDLMAA |
| 135 | MAAQARLKDLEALLN |
| 155 | LSTALSEKRTLEGEL |
| 171 | DLRGQVAKLEAALGE |
| 180 | EAALGEAKKQLQDEM |
| 201 | ENRLQTLKEELDFQK |
| 233 | LVEIDNGKQREFESR |
| 260 | EDQVEQYKKELEKTY |
| 265 | QYKKELEKTYSAKLD |
| 270 | LEKTYSAKLDNARQS |
| 316 | LQKQLAAKEAKLRDL |
| 32 | RITRLQEKEDLQELN |
| 341 | SRRLLADKEREMAEM |
| 417 | QSGGSVTKKRKLESS |
| 420 | GSVTKKRKLESSESR |
| 450 | EEVDEEGKFVRLRNK |
| 486 | LTYRFPPKFTLKAGQ |
| 78 | SREVSGIKSAYEAEL |
| 90 | AELGDARKTLDSVAK |
| 97 | KTLDSVAKERARLQL |
Function
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence
Protein Sequence
10
METPSQRRAT
20
RSGAQASSTP
30
LSPTRITRLQ
40
EKEDLQELND
50
RLAVYIDRVR
60
SLETENAGLR
70
LRITESEEVV
80
SREVSGIKSA
90
YEAELGDARK
100
TLDSVAKERA
110
RLQLELSKVR
120
EEFKELKARN
130
TKKEGDLMAA
140
QARLKDLEAL
150
LNSKEAALST
160
ALSEKRTLEG
170
ELHDLRGQVA
180
KLEAALGEAK
190
KQLQDEMLRR
200
VDAENRLQTL
210
KEELDFQKNI
220
YSEELRETKR
230
RHETRLVEID
240
NGKQREFESR
250
LADALQELRA
260
QHEDQVEQYK
270
KELEKTYSAK
280
LDNARQSAER
290
NSNLVGAAHE
300
ELQQSRIRID
310
SLSAQLSQLQ
320
KQLAAKEAKL
330
RDLEDSLARE
340
RDTSRRLLAD
350
KEREMAEMRA
360
RMQQQLDEYQ
370
ELLDIKLALD
380
MEIHAYRKLL
390
EGEEERLRLS
400
PSPTSQRSRG
410
RASSHSSQTQ
420
SGGSVTKKRK
430
LESSESRSSF
440
SQHARTSGRV
450
AVEEVDEEGK
460
FVRLRNKSNE
470
DQSMGNWQIK
480
RQNGDDPLLT
490
YRFPPKFTLK
500
AGQVVTIWAA
510
GAGATHSPPA
520
DLVWKSQNTW
530
GCGNSLRTAL
540
INSTGEEVAM
550
RKLVRSVTMI
560
EDDEDEDGDD
570
LLHHHHGSHG
580
SSSGDPAEYN
590
LRSRTVLCGT
600
CGQPADKASA
610
SSSGAQVGGS
620
ISSGSSASSV
630
TVTRSYRSVG
640
GSGGGSFGDN
650
LVTRSYLLGN
660
SRPRTQVSCP
670
SMSTAPGPVG
680
VGGSAFSSAA
690
RGSGSLLPAA
700
QYPRQSLLRP
APPV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005638 | lamin filament |
| Cellular Component | GO:0005652 | nuclear lamina |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0160123 | structural constituent of nuclear lamina |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:1990683 | DNA double-strand break attachment to nuclear envelope |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0006998 | nuclear envelope organization |
| Biological Process | GO:0007097 | nuclear migration |
| Biological Process | GO:0051664 | nuclear pore localization |
| Biological Process | GO:0090435 | protein localization to nuclear envelope |
| Biological Process | GO:0030334 | regulation of cell migration |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.