Search Results
Overview
| Uniprot ID | A0A480PIW7 |
|---|---|
| Protein Name | Translation initiation factor eIF2B subunit gamma |
| Gene Name | EIF2B3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 165 | VGVDSTGKRLLFMAN |
Function
Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed
Protein Sequence
10
MEFQAVVMAV
20
GGGSRMTDLT
30
SSVPKPLLPV
40
GNKPLIWYPL
50
NLLERVGFEE
60
VIVITTRDVQ
70
KALCADFKMK
80
MKLDIVCIAD
90
DADIGTADSL
100
RYIYQKLKTD
110
VLVLSCDLIT
120
DVALHEVVDL
130
FRAHDATLAM
140
LMRKGQDGLE
150
SVPGQKGKKK
160
AVEQRDFVGV
170
DSTGKRLLFM
180
ANEADLDEEL
190
VIKGAILQKH
200
PRIRFHTGLV
210
DAHLYCLRRY
220
VVDFLMEYKS
230
ITSIRSELIP
240
YLVRKQFSSA
250
SSQQGQEEKE
260
EELKKKELKT
270
LDIYSFIKEV
280
GPLTFALHDA
290
CWNACRGDSR
300
EDLSRSQVRC
310
YVHIMKEGLC
320
SRVGTLGLYM
330
EANRQVSKLL
340
PVICPEETLV
350
HPSAQIVSKH
360
LIGADSLIGP
370
DTQVGEKSSV
380
KRSVIGSSCV
390
IRDRVTVTNS
400
LLMNSVTVEE
410
GSNIQGSVIC
420
NNAVIEKGAD
430
IKDCLIGNGQ
440
RIEAKAQLMR
450
LSLAKVLATS
CSAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005851 | eukaryotic translation initiation factor 2B complex |
| Molecular Function | GO:0005085 | guanyl-nucleotide exchange factor activity |
| Molecular Function | GO:0003743 | translation initiation factor activity |
| Biological Process | GO:0007417 | central nervous system development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.