Search Results
Overview
| Uniprot ID | A0A480PW82 |
|---|---|
| Protein Name | Kinetochore protein SPC25 |
| Gene Name | SPC25 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 65 | SLKAFAEKLSVKLKE |
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules
Protein Sequence
10
MGQAAGLKPA
20
GDALSYKMVE
30
DELALFDKSI
40
NEFWNRFKST
50
VSDTSCQMVG
60
LRENYKDSLK
70
AFAEKLSVKL
80
KEEERMVEMF
90
LEYQNQIDRQ
100
NKLIQEKKDN
110
LLKLIAEVKD
120
KSQELEALTA
130
NIQDLKEEYA
140
RKKETISTAN
150
RANEERLKRL
160
QKSADLYKDR
170
LGLEIRKIYG
180
DKLQFIFTNI
190
DPKHPEIPFM
200
FTLSLNEARD
210
YEVSDSAPYL
220
ECLAEFQENV
230
RKTNNFSAFL
240
ANVRKAFTAM
VYN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031262 | Ndc80 complex |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0008608 | attachment of spindle microtubules to kinetochore |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0007052 | mitotic spindle organization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.