Search Results
Overview
| Uniprot ID | A0A480S312 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit, mitochondrial |
| Gene Name | IDH3A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 177 | LITEGASKRIAEFAF |
| 223 | REVAENCKDIKFNEM |
| 336 | TACFATIKDGKSLTK |
| 343 | KDGKSLTKDLGGNAK |
| 58 | MKIFDAAKAPIQWEE |
Function
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MAGPAWISKV
20
SRLLGAFRNQ
30
KQVTRGFAGG
40
VKTVTLIPGD
50
GIGPEISAAV
60
MKIFDAAKAP
70
IQWEERNVTA
80
IQGPGGKWMI
90
PPEAKESMDK
100
NKMGLKGPLK
110
TPIAAGHPSM
120
NLLLRKTFDL
130
YANVRPCVSI
140
EGYKTPYTDV
150
NIVTIRENTE
160
GEYSGIEHVI
170
VDGVVQSIKL
180
ITEGASKRIA
190
EFAFEYARNN
200
HRSNVTAVHK
210
ANIMRMSDGL
220
FLQKCREVAE
230
NCKDIKFNEM
240
YLDTVCLNMV
250
QDPSQFDVLV
260
MPNLYGDILS
270
DLCAGLIGGL
280
GVTPSGNIGA
290
NGVAIFESVH
300
GTAPDIAGKD
310
MANPTALLLS
320
AVMMLRHMGL
330
FDHAAKIETA
340
CFATIKDGKS
350
LTKDLGGNAK
360
CSDFTEEICR
RVKDLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045242 | isocitrate dehydrogenase complex (NAD+) |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004449 | isocitrate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006102 | isocitrate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.