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Overview

Uniprot ID	A0A480T8S4
Protein Name	Mitochondrial-processing peptidase subunit beta
Gene Name	PMPCB
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
224	NIKSINRKDLVDYIT
456	TIREVCTKYIYDKSP

Function

Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis

Protein Sequence

10 MAAAAARAVF 20 LPAVRKRLWG 30 FSKRLLVGGP 40 ARQSLYFGGN 50 RLRSTQAATQ 60 VFLNVPETRV 70 TCLENGLRVA 80 SEDSGLSTCT 90 VGLWIDAGSR 100 YENEKNNGTA 110 HFLEHMAFKG 120 TKKRSQLDLE 130 LEIENMGAHL 140 NAYTSREQTV 150 YYAKAFSKDL 160 PRAVEILADI 170 IQNSTLGEAE 180 IERERGVILR 190 EMQEVETNLQ 200 EVVFDYLHAT 210 AYQNTALGRT 220 ILGPTENIKS 230 INRKDLVDYI 240 TTHYKGPRIV 250 LAAAGGVSHD 260 ELLELAKFHF 270 GDSLSPDEGE 280 IPALPPCKFT 290 GSEIRVRDDK 300 MPLAHLAIAV 310 EAVGWAHPDT 320 ICLMVANTLI 330 GNWDRSFGGG 340 MNLSSKLAQL 350 TCHGNLCHSF 360 QSFNTSYTDT 370 GLWGIYMVCE 380 PATVADMLHV 390 VQKEWMRLCT 400 SVTESEVARA 410 KNLLKTNMLL 420 QLDGSTPICE 430 DIGRQMLCYN 440 RRIPIPELEA 450 RIDAVNAETI 460 REVCTKYIYD 470 KSPAVAAVGP 480 IEQLPDFNQI RSNMCWLRD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0017087	mitochondrial processing peptidase complex
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006627	protein processing involved in protein targeting to mitochondrion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.