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Overview

Uniprot IDA0A480U2S8
Protein NameU5 small nuclear ribonucleoprotein 40 kDa protein
Gene NameSNRNP40
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
149 GERVKRLKGHTSFVN
18 ELPLVPVKRQRHELL
271 DVRPFAPKERCVKIF
8 MIEQQKRKGPELPLV

Function

Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs

Protein Sequence

10 MIEQQKRKGP 20 ELPLVPVKRQ 30 RHELLLGAAG 40 SGPGAGQQQA 50 APGALLQAGP 60 PRCSSLQAPI 70 MLLSGHEGEV 80 YCCKFHPNGS 90 TLASAGFDRL 100 ILLWNVYGDC 110 DNYATLKGHS 120 GAVMELHYNT 130 DGSMLFSAST 140 DKTVAVWDSE 150 TGERVKRLKG 160 HTSFVNSCYP 170 ARRGPQLVCT 180 GSDDGTVKLW 190 DIRKKAAIQT 200 FQNTYQVLAV 210 TFNDTSDQII 220 SGGIDNDIKV 230 WDLRQNKLTY 240 TMRGHADSVT 250 GLSLSSEGSY 260 LLSNAMDNTV 270 RVWDVRPFAP 280 KERCVKIFQG 290 NVHNFEKNLL 300 RCSWSPDGSK 310 IAAGSADRFV 320 YVWDTTSRRI 330 LYKLPGHAGS 340 INEVAFHPDE 350 PIILSASSDK RLYMGEIQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Cellular Component GO:0005682 U5 snRNP
Biological Process GO:0006397 mRNA processing
Biological Process GO:0000375 RNA splicing, via transesterification reactions

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.