Search Results
Overview
| Uniprot ID | A0A480U8W8 |
|---|---|
| Protein Name | YTH domain-containing family protein |
| Gene Name | YTHDF3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 449 | CSTEHGNKRLDAAYR |
Function
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing
Protein Sequence
10
MFYLDLTLLH
20
RAEETGEESF
30
SVQNGSIHQK
40
DAVNDDDFEP
50
YLSSQTNQNN
60
SYPPMSDPYM
70
PSYYAPSIGF
80
PYSLGEAAWS
90
TAGDQPMPYL
100
TTYGQMSNGE
110
HHYIPDGVFS
120
QPGALGNTPP
130
FLGQHGFNFF
140
PGNADFSTWG
150
TSGSQGQSTQ
160
SSAYSSSYGY
170
PPSSLGRAIT
180
DGQAGFGNDT
190
LSKVPGISSI
200
EQGMTGLKIG
210
GDLTAAVTKT
220
VGTALSSSGM
230
TSIATNSVPP
240
VSSAAPKPTS
250
WAAIARKPAK
260
PQPKLKPKGN
270
VGIGGSAVPP
280
PPIKHNMNIG
290
TWDEKGSVVK
300
APPTQPVLPP
310
QTIIQQPQPL
320
IQPPPLVQSQ
330
LPQQQPQPPQ
340
PQQQQGPQPQ
350
AQPHQVQPQQ
360
QQLQNRWVAP
370
RNRGAGFNQN
380
NGAGGENFGL
390
GVVPVSASPS
400
SVEVHPVLEK
410
LKAINNYNPK
420
DFDWNLKNGR
430
VFIIKSYSED
440
DIHRSIKYSI
450
WCSTEHGNKR
460
LDAAYRSLNG
470
KGPLYLLFSV
480
NGSGHFCGVA
490
EMKSVVDYNA
500
YAGVWSQDKW
510
KGKFEVKWIF
520
VKDVPNNQLR
530
HIRLENNDNK
540
PVTNSRDTQE
550
VPLEKAKQVL
560
KIIATFKHTT
570
SIFDDFAHYE
580
KRQEEEEAMR
RERNRNKQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0000932 | P-body |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:1990247 | N6-methyladenosine-containing RNA reader activity |
| Molecular Function | GO:0043022 | ribosome binding |
| Biological Process | GO:0061157 | mRNA destabilization |
| Biological Process | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:0045948 | positive regulation of translational initiation |
| Biological Process | GO:1901163 | regulation of trophoblast cell migration |
| Biological Process | GO:0034063 | stress granule assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.