Search Results
Overview
| Uniprot ID | A0A480U8Y2 |
|---|---|
| Protein Name | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
| Gene Name | SUCLG1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 182 | VINPGECKIGIMPGH |
| 192 | IMPGHIHKKGRIGIV |
| 57 | LYVDKNTKVICQGFT |
| 93 | TTPGKGGKTHLGLPV |
Function
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase
Protein Sequence
10
MTAGLVAAPA
20
AATMASGSSG
30
LAAARLLSRS
40
FLLQQNGIRH
50
CSYTASRKHL
60
YVDKNTKVIC
70
QGFTGKQGTF
80
HSQQALEYGT
90
NLVGGTTPGK
100
GGKTHLGLPV
110
FNTVKEAKEQ
120
TGATASVIYV
130
PPPFAAAAIN
140
EAIDAEVPLV
150
VCITEGIPQQ
160
DMVRVKHRLL
170
RQGKTRLIGP
180
NCPGVINPGE
190
CKIGIMPGHI
200
HKKGRIGIVS
210
RSGTLTYEAV
220
HQTTQVGLGQ
230
SLCVGIGGDP
240
FNGTDFTDCL
250
EIFLNDPATE
260
GIILIGEIGG
270
NAEENAAEFL
280
KQHNSGPKSK
290
PVVSFIAGLT
300
APPGRRMGHA
310
GAIIAGGKGG
320
AKEKITALQS
330
AGVVVSMSPA
340
QLGTTIYKEF
EKRKML
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045244 | succinate-CoA ligase complex (GDP-forming) |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0004775 | succinate-CoA ligase (ADP-forming) activity |
| Molecular Function | GO:0004776 | succinate-CoA ligase (GDP-forming) activity |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.