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Overview

Uniprot IDA0A480UUW0
Protein NameReplication factor C subunit 3
Gene NameRFC3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
218 LARKLAEKSCRNLRK

Function

Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA

Protein Sequence

10 MSLWVDKYRP 20 CSLGQLDYHK 30 EQAAQLRNLV 40 QCGDFPHLLV 50 YGPSGAGKKT 60 RIMCILRELY 70 GVGVEKLRIE 80 HQTITTPSKK 90 KIEISTIASN 100 YHLEVNPSDA 110 GNSDRVVIQE 120 MLKTVAQSQQ 130 LETNSQKDFK 140 VVLLTEVDKL 150 TKDAQHALRR 160 TMEKYMSTCR 170 LILCCNSTSK 180 VIPPIRSRCL 190 AVRVPAPSIE 200 DICHVLSTVC 210 KKEGLSLPSQ 220 LARKLAEKSC 230 RNLRKALLMC 240 EACRVQQYPF 250 TVDQEIPETD 260 WEVYLRETAN 270 AIVSQQTPQR 280 LLEVRGRLYE 290 LLTHCIPPEI 300 IMKGLLSELL 310 HNCDGQLKGE 320 VAQMAAYYEH 330 RLQLGSKAIY 340 HLEAFVAKFM 350 ALYKKFMEDG LEGMIF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031390 Ctf18 RFC-like complex
Cellular Component GO:0005663 DNA replication factor C complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003689 DNA clamp loader activity
Molecular Function GO:0017116 single-stranded DNA helicase activity
Biological Process GO:0006281 DNA repair
Biological Process GO:0006271 DNA strand elongation involved in DNA replication
Biological Process GO:0006261 DNA-templated DNA replication

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.