Overview
| Uniprot ID | A0A480V341 |
|---|
| Protein Name | Cyclin-dependent kinase 14 |
|---|
| Gene Name | CDK14 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 164 |
NGKLVALKVIRLQEE |
Function
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport
Protein Sequence
10
MCDLIEPQPA
20
EKIGKMKKLR
30
RTLSDSFSRI
40
ALKKDDTTFD
50
EICVTKMSTR
60
NCPGMDSMIK
70
PLDTIPEDKK
80
VRVQRTQSTF
90
DPFEKPANQV
100
KRVHSENNAC
110
INFKTSSAGK
120
ESPKVRRHSS
130
PSSPTSPKFG
140
KADSYEKLEK
150
LGEGSYATVY
160
KGKSKVNGKL
170
VALKVIRLQE
180
EEGTPFTAIR
190
EASLLKGLKH
200
ANIVLLHDII
210
HTKETLTLVF
220
EYVHTDLCQY
230
MDKHPGGLHP
240
ENVKLFLFQL
250
LRGLSYIHQR
260
YILHRDLKPQ
270
NLLISDTGEL
280
KLADFGLARA
290
KSVPSHTYSN
300
EVVTLWYRPP
310
DVLLGSTEYS
320
TCLDMWGVGC
330
IFVEMIQGVA
340
AFPGMKDIQD
350
QLERIFLVLG
360
TPNEDTWPGV
370
HSLPHFKPER
380
FTLYSSKNLR
390
QAWNKLSYVN
400
HAEDLASKLL
410
QCSPKNRLSA
420
QAALSHEYFS
430
DLPPRLWELT
440
DMSSIFTVPN
450
VRLQPEAGES
460
TRAFGKNNSY
GKSLSNSKH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0000308 |
cytoplasmic cyclin-dependent protein kinase holoenzyme complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0030332 |
cyclin binding |
| Molecular Function |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0000086 |
G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0060828 |
regulation of canonical Wnt signaling pathway |
| Biological Process |
GO:1901987 |
regulation of cell cycle phase transition |
| Biological Process |
GO:0016055 |
Wnt signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.