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Overview

Uniprot ID	A0A480WLU7
Protein Name	Threonine--tRNA ligase, mitochondrial
Gene Name	TARS2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
222	KLRLIDEKITGPKAT

Function

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain

Protein Sequence

10 MGLYRRWRRL 20 RLPGLQACGL 30 HTAAVPTPPH 40 WLVERLGFFE 50 ELWTAQVKKL 60 ASMAQKEHRA 70 IKVSLPGGRK 80 VDAVAWNTTP 90 YQLAQQISSK 100 LADTAVAAVV 110 NGEPYDLERP 120 LEKDSDLRFL 130 TFDSAEGKAV 140 FWHSSTHVLG 150 AAAEQFLGAV 160 LCQGPSTECG 170 FYHDFFLGKE 180 RTVRGSELPV 190 LEQICQELAA 200 AAQPFRRLEA 210 SRDQLRQLFK 220 DNPFKLRLID 230 EKITGPKATV 240 YGCGMLVDLC 250 RGPHLRHTGQ 260 IGGLKLLTNS 270 SSLWKFSGTP 280 ETLQRVSGIS 290 FPTAEELRAW 300 EEWREEAELR 310 DHRRIGKEQE 320 LFFFHELSPG 330 SCFFLPRGTR 340 VYNALVAFIR 350 AEYTRRGFLE 360 VKTPTLFSTK 370 LWELSGHWEH 380 YREDMFALQP 390 SGTDGPASSQ 400 SDHSTSHPTD 410 TLALKPMNCP 420 AHCLMFAHRP 430 RSWRELPLRL 440 ADFGALHRAE 450 ASGSLGGLTR 460 LRCFQQDDAH 470 IFCAPDQLEA 480 EIRGCLDFLR 490 SVYTVLGFSF 500 RLALSTRPSG 510 FLGEPCLWDQ 520 AEQVLQQALE 530 EFGEPWDLNP 540 GDGAFYGPKI 550 DVHVRDALGR 560 PHQCGTIQLD 570 FQLPLRFDLQ 580 YKGQAEALER 590 PVLIHRAVLG 600 SVERMLGVLA 610 ESCGGKWPLW 620 LSPFQVVVIP 630 VGSEQEEYAR 640 EAQQSLRAAG 650 LVGDLDADSG 660 LTLSRRVRRA 670 QLAHYNFQFV 680 VGQKEQSKRT 690 VNIRTRDNHR 700 LGERDLAEAV 710 QRLLELQNTR VPNAEEIF

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0002161	aminoacyl-tRNA deacylase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0004829	threonine-tRNA ligase activity
Biological Process	GO:0006435	threonyl-tRNA aminoacylation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.