Search Results
Overview
| Uniprot ID | A0A480WYK9 |
|---|---|
| Protein Name | Cation-dependent mannose-6-phosphate receptor |
| Gene Name | M6PR |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 39 | TCDLVGEKGKESEKE |
| 45 | EKGKESEKELALLKR |
| 51 | EKELALLKRLKPLFN |
| 54 | LALLKRLKPLFNKSF |
Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex
Protein Sequence
10
MVPVDSSWRT
20
GLPLLLLLAV
30
AVRGSWQAEE
40
KTCDLVGEKG
50
KESEKELALL
60
KRLKPLFNKS
70
FESTVGQGSD
80
TYMYMFRVCR
90
EAGNHSSGAG
100
LVQINKSNGK
110
ETVVGRLNET
120
HVFNGSNWIM
130
LIYKGGDEYD
140
NHCGKEQRRA
150
VVMISCNRHT
160
LADNFNPVSE
170
ERGKVQDCFY
180
LFEMDSSLAC
190
SPEISHLSVG
200
SILLVTFASL
210
VAVYIIGGFL
220
YQRLVVGAKG
230
IEQFPHLAFW
240
QDLGNLVADG
250
CDFVCRSKPR
260
NVPAAYRGVG
270
DDQLGEESEE
RDDHLLPM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005770 | late endosome |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:1905394 | retromer complex binding |
| Biological Process | GO:0006622 | protein targeting to lysosome |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.