Search Results
Overview
| Uniprot ID | A0A480YT82 |
|---|---|
| Protein Name | Acyl-coenzyme A oxidase |
| Gene Name | ACOX1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 295 | EAARCLSKACTIAIR |
Function
Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2))
Protein Sequence
10
MNQDLQKERA
20
AASFNPELLT
30
HVLDGSPENT
40
RRRREIENMI
50
LSDPDLQHED
60
LNFLSRSQRY
70
EVAVKKSATT
80
VKKIREFGLA
90
DPDEILWFKK
100
LHLVNFVEPV
110
GLNYSMFIPT
120
LLSQGTTAQR
130
EKWLPPSKRL
140
EIIGTYAQTE
150
LGHGTHLRGL
160
ETTATYDPAT
170
EEFILNSPTV
180
TSIKWWPGGL
190
GKTSNHAIVL
200
AQLITQGKCY
210
GLHAFIVPIR
220
EQGTHKPLPG
230
ITVGDIGPKF
240
GYDEMDNGYL
250
KMDNYRIPRE
260
NMLMKYAQVK
270
PDGTYVKPLS
280
NKLTYGTMVF
290
IRSFLVGEAA
300
RCLSKACTIA
310
IRYSAVRHQS
320
ELRPDEPEPQ
330
ILDYQTQQYK
340
LFPFLATAYA
350
FQFVGAYIKE
360
TYHRINENIR
370
QGDLSGLPEL
380
HALTAGLKAF
390
TSWTANAAIE
400
ACRMACGGHG
410
YSHCSGLPNI
420
YVNFTPTCTF
430
EGENTVMMLQ
440
TARFLMKSYN
450
QVHSGKLVCG
460
MVSYLNDLPS
470
QRIQPQQVAA
480
WPTVADINSP
490
DSLIEAYRLR
500
ASRLVEIAAK
510
NLQTEMSHRK
520
SKEAAWNLTS
530
IDLVRASEAH
540
CHYVVVKLFA
550
EKLHQIQERS
560
IHAVLRNLCL
570
LYALYGISQN
580
SGDFLQGSIM
590
TESQVTHVNE
600
RVKELLMAIR
610
PEAVALVDAF
620
DFQDVTLGSV
630
LGRYDGNVYE
640
NMFEWAKKSP
650
LNKTEVHESY
660
HKHLKSLQSK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0005504 | fatty acid binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0120524 | long-chain fatty acyl-CoA oxidase activity |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0006091 | generation of precursor metabolites and energy |
| Biological Process | GO:0050665 | hydrogen peroxide biosynthetic process |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0140493 | very long-chain fatty acid beta-oxidation |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.