Search Results
Overview
| Uniprot ID | A0A480ZVP3 |
|---|---|
| Protein Name | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
| Gene Name | CNP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 161 | RLDCAQLKEKNHWQL |
| 163 | DCAQLKEKNHWQLSA |
| 254 | GVLHCTTKFCDYGKA |
| 274 | YAQQEVVKKSYSKAF |
Function
Myelin-associated enzyme that catalyzes the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. In the mitochondria, regulates the functioning of the mitochondrial permeability transition pore (mPTP), and thus is involved in the mechanisms of cell death, both apoptosis and necrosis. Acts as an antiviral factor by suppressing the assembly of SARS-CoV-2 virions
Protein Sequence
10
MNRGFSRKSQ
20
TFLPKIFFRK
30
MSSSGAKDKP
40
ELQFPFLQDE
50
ETVATLQECK
60
TLFILRGLPG
70
SGKSTLAQVI
80
MDRYRDGTKV
90
VSADAYKITP
100
GARGAFTEEY
110
KRLDEDLAAC
120
CRRDIRVLVL
130
DDTNHERERL
140
EQLFEMADQY
150
QYQVVLVEPK
160
TAWRLDCAQL
170
KEKNHWQLSA
180
DDLKKLKPGL
190
EKDFLPLYFG
200
WFLSRKSSES
210
LRKAGQTFLE
220
ELGNHKAFKK
230
ELRHFGSGDE
240
PREKMELVAY
250
FGKRPPGVLH
260
CTTKFCDYGK
270
AAGAEEYAQQ
280
EVVKKSYSKA
290
FVLTISALFV
300
TPKTTGARVE
310
LSEQELALWP
320
NDVDKLSPSD
330
SLPRGSRAHI
340
TLGCAGDVEA
350
VQTGLDLLEI
360
VRQEKGGSRG
370
EEVGELSRGK
380
LYSLGNGRWM
390
LSLAKKMEVR
400
AIFTGYYGKG
410
KAVPTRGGRK
420
GGSFQSCAIL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0009214 | cyclic nucleotide catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.