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Overview

Uniprot IDA0A481A893
Protein NameThioredoxin domain-containing protein 12
Gene NameTXNDC12
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
69 KSWCGACKALKPKFA

Function

Protein-disulfide reductase of the endoplasmic reticulum that promotes disulfide bond formation in client proteins through its thiol-disulfide oxidase activity

Protein Sequence

10 MEPRPRLGAT 20 CLLGFSFLLL 30 VSSDGHVGLG 40 KGFGDHIHWR 50 TLEDGKKEAA 60 ASGLPLMVII 70 HKSWCGACKA 80 LKPKFAESTE 90 ISELAHNFVM 100 VNLEDEEEPK 110 DEDFSPDGGY 120 IPRILFLDPS 130 GKVRPEIINE 140 HGNPSYKYFY 150 VNAEQVVQGM 160 KEAQERLTGD 170 AFREKHLEDE L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Molecular Function GO:0019153 protein-disulfide reductase (glutathione) activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.