Search Results

Overview

Uniprot IDA0A481AFG9
Protein NameNuclear pore complex protein Nup153
Gene NameNUP153
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1060 SVAPFTCKTPEAKKE
670 QNKVADNKCVACQAT
686 LPPRDTAKQLGTGTP
742 CVACETPKPGTGVKR

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Protein Sequence

10 MASGAGGLGG 20 GGGGKIRTRR 30 CHQGPIKPYQ 40 QGRQQHQGIL 50 SRVTESVKNI 60 VPGWLQRYFN 70 KNEDVCSCST 80 DTREVPQWPE 90 NREDDHTMYA 100 DEEGASVHDG 110 RITPEPTVSN 120 TEEPSTTSTA 130 SNYPDVLTRP 140 SLHRSHLNFS 150 MLESPALHCQ 160 PSTSSAFPIG 170 SSGFSLVKEI 180 KDSTSQHDDD 190 NISTTSGFSS 200 RASDKDIAVS 210 KNTSVPPLWS 220 PEAERSHSLS 230 QHTATSSKKP 240 AFNLSAFGTL 250 SPSLGNSSIL 260 KTSQLGDSPF 270 YPGKTMYGGA 280 AAAVRQPKLQ 290 NTPYQAPVRR 300 QMKAKQLNAQ 310 SYGVTSSTAR 320 RILQSLEKMS 330 SPLADAKRIP 340 SVFSSLNSSL 350 DRSGIDNTTD 360 LQAKRRKVDS 370 QNPPVQGLMT 380 PKPVSIAANR 390 TVYFKPSLTP 400 SGELRKTNQR 410 VDKKHSTGYE 420 KNMSPGQNKE 430 RESGFSYPNF 440 SMSAANGLSS 450 GVGSGGGKMR 460 RERTRFVASK 470 PQDEEEMEVP 480 VLPKISLPIT 490 SSSLPTFNFS 500 SSVITTSSPS 510 PISPSQSLTN 520 KVQMTSPNST 530 GSPLFRFSSP 540 IVKSTEADVL 550 PPSSIGFTFS 560 VPVAKTELSG 570 SSTISEPIMS 580 SSVNNSTSCK 590 KADEDGEGLF 600 RPAKTLKEGS 610 VLDVLKNPGF 620 TSPKADSPAA 630 QPTTTSPIVY 640 TRPAISSSSS 650 SGIGFGESLK 660 AGPSWQCDTC 670 LLQNKVADNK 680 CVACQATKLP 690 PRDTAKQLGT 700 GTPSKSGKPT 710 LSSPGTGFGD 720 KFKPAVGTWD 730 CDTCLVQNKP 740 EAIKCVACET 750 PKPGTGVKRV 760 FTLPVASESA 770 VTMAASSSSC 780 TVTTGALGFT 790 DKFKRPMGSW 800 ECPVCCVSNN 810 AEDNKCVSCM 820 SEKPGSSVPA 830 SSSSTVPVSV 840 LSGGSLGLDK 850 FKKPEGNWNC 860 DVCLVENKAD 870 STKCIACESA 880 KPGTKSEFKG 890 FGTSSSSLNP 900 ATSSFKFGIP 910 SSSSAPSQTL 920 TNTGNFKFGD 930 QGGFKIGVSS 940 DLGSVNPMSE 950 EGFKFPKPIG 960 DFKFGVSSDS 970 KPEEVKKDSK 980 NDNNFKFGLS 990 SGLSNPAPLA 1000 PFQFGVSNLG 1010 QQEKKEEVPE 1020 SSSAGFSFCS 1030 GVINPPPLAA 1040 DTKVTSESKN 1050 SFSFGTTDTK 1060 SVSVAPFTCK 1070 TPEAKKEETP 1080 VTKGGFTFGS 1090 MDSAPLPSAS 1100 FVLGRTEEKQ 1110 QEPVTSTSLV 1120 FGKKVDTEEP 1130 KCQPVFSFGN 1140 SEQTKDEGSS 1150 KSTFSFSTAK 1160 PSEKESEQPA 1170 KATFAFGAQT 1180 STTADQGAAK 1190 PVFSFLNNNS 1200 SNSSTPATSA 1210 GGGIFGSSTT 1220 SSSAPVAAFV 1230 FGQASNPVSS 1240 SAFGNSAESS 1250 TSQSLLFSQE 1260 SKPATTSSTG 1270 TAVTPFVFGP 1280 GPSSNNTATS 1290 GFTFGATTTS 1300 SSAGSSFVFG 1310 TGPSAPSASP 1320 AFGANQTPTF 1330 GQSQGASQPN 1340 PPGFGSIASS 1350 AALFSAGSQP 1360 APPTFGTVSS 1370 SSQPPVFGQQ 1380 PSQSAFGSGT 1390 APNSSSVFQF 1400 GSSTTNFNFT 1410 NNNPSGVFTF 1420 GANPSIPAAS 1430 AQPSGSGGFP 1440 FNQSPGAFTV 1450 GSNGKNIFSS 1460 SGTSLSGRKI KTAVRRRK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0044615 nuclear pore nuclear basket
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0140693 molecular condensate scaffold activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0043495 protein-membrane adaptor activity
Molecular Function GO:0017056 structural constituent of nuclear pore
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:1990000 amyloid fibril formation
Biological Process GO:0051028 mRNA transport
Biological Process GO:0046832 negative regulation of RNA export from nucleus
Biological Process GO:0051292 nuclear pore complex assembly
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0006405 RNA export from nucleus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.