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Overview

Uniprot IDA0A481B9G9
Protein NameProbable E3 ubiquitin-protein ligase HERC4
Gene NameHERC4
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1029 DLPKYTDKETLRSKL

Function

Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates

Protein Sequence

10 MLCWGNASFG 20 QLGLGGIDEE 30 IVLEPRKSDF 40 FINKKVRDVG 50 CGLRHTVFVL 60 DDGTVYTCGC 70 NDLGQLGHEK 80 SRKKPEQVVA 90 LDAQNIVAVS 100 CGEAHTLALN 110 DKGQVYAWGL 120 DSDGQLGLLG 130 TEECIRVPRN 140 IKSLSDIQIV 150 QVACGYYHSL 160 ALSKASEVFC 170 WGQNKYGQLG 180 LGIDCKKQSS 190 PQLIKSLLGI 200 PFMQVAAGGA 210 HSFVLTLSGA 220 IFGWGRNKFG 230 QLGLNDENDR 240 YVPNLLKSLR 250 TQKIVYICCG 260 EDHTAALTKE 270 GGVFTFGAGG 280 YGQLGHNSTS 290 HEINPRKVFE 300 LMGSIVTQIA 310 CGRQHTSAFV 320 PSSGRIYSFG 330 LGGNGQLGTG 340 STSNRKSPFT 350 VKGNWFPYNG 360 QCPPDFDSEE 370 YFCVKRIFSG 380 GDQSFSHYSN 390 PQNCGPPDDF 400 RFSDPSKQIW 410 TVNEALIQKW 420 LSYPSGRFPV 430 EIANEIDGTF 440 SSSGCLNGSF 450 LAVSNDDHYR 460 TGTRFSGVDM 470 NAARLLFHKL 480 IQPDHPQISQ 490 QVAASLEKNL 500 IPKLTSSLPD 510 VEALRFYLTL 520 PECPLMSDSN 530 NFTTIAIPFG 540 TALVNLEKAP 550 LKVLENWWSV 560 LEPPLFLKIV 570 ELFKEVVVHL 580 LKLYKIGIPP 590 SERRIFNSFL 600 HTALKVLEIL 610 HRVNEKTGQI 620 IQYDKFYIHE 630 VQELIDIRND 640 YINWVQQQAY 650 GMLADIPVTI 660 CTYPFVFDAQ 670 AKTTLLQTDA 680 VLQMQMAIDQ 690 AHRQNVSSLF 700 LPVIESVNPC 710 LILVVRRENI 720 VGDAMEVLRK 730 TKNIDYKKPL 740 KVIFVGEDAV 750 DAGGVRKEFF 760 LLIMRELLDP 770 KYGMFRYYED 780 SRLIWFSDKT 790 FEDSDLFHLI 800 GVICGLAIYN 810 FTIVDLHFPL 820 ALYKKLLKKK 830 PSLDDLKELV 840 PDVGRSMQQL 850 LDYPEDDVEE 860 TFCLNFTITV 870 ENFGATEVKE 880 LVLNGADTAV 890 NKQNRQEFVD 900 AYVDYIFNKS 910 VASLFDAFHA 920 GFHKVCGGKV 930 LQLFQPNELQ 940 AMVIGNTNYD 950 WKELEKNTEY 960 KGEYWAEHPT 970 IKMFWEVFHE 980 LPLEKKKQFL 990 LFLTGSDRIP 1000 ILGMKSLILV 1010 IQSTGGGEEY 1020 LPVSHTCFNL 1030 LDLPKYTDKE 1040 TLRSKLIQAI DHNEGFSLI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0061630 ubiquitin protein ligase activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0045879 negative regulation of smoothened signaling pathway
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.