Overview
| Uniprot ID | A0A481C371 |
|---|
| Protein Name | Vasodilator-stimulated phosphoprotein |
|---|
| Gene Name | VASP |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 241 |
AKLKKVSKQEEAAGG |
| 277 |
AMLARRRKATQVGEK |
| 313 |
SVRRPWEKNSTTLPR |
| 322 |
STTLPRMKSSSSVTA |
Function
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation
Protein Sequence
10
MSETVICSSR
20
ATVMLYDDSN
30
KRWLPAGTGP
40
QAFSRVQIYH
50
NPTANSFRVV
60
GRKMQPDQQV
70
VINCAIVRGV
80
KYNQATPNFH
90
QWRDARQVWG
100
LNFGSKEDAT
110
QFASGMASAL
120
EALEGGGPPP
130
PPPAAAPPTW
140
SVQNGPAPEE
150
LEQQKRQQQP
160
EHLERRVSNA
170
GGPPAPPSGG
180
PPLPPGPPPP
190
PGPPPPPGLS
200
SSGVSAAGPG
210
AGGGPPPPPP
220
LPTAQGPSGG
230
GAGAPGLAAA
240
IAGAKLKKVS
250
KQEEAAGGPV
260
APKAESSRST
270
GGGLMEEMNA
280
MLARRRKATQ
290
VGEKPTKDES
300
ANQEEPEPRV
310
PAHTESVRRP
320
WEKNSTTLPR
330
MKSSSSVTAS
340
EAHPATSSSS
350
DESDLERVKQ
360
ELLEEVRKEL
370
QKVKQEIIEA
380
FVQELRKRGS
P
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031527 |
filopodium membrane |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0031258 |
lamellipodium membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005522 |
profilin binding |
| Molecular Function |
GO:0017124 |
SH3 domain binding |
| Biological Process |
GO:0008154 |
actin polymerization or depolymerization |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:0001843 |
neural tube closure |
| Biological Process |
GO:0030838 |
positive regulation of actin filament polymerization |
| Biological Process |
GO:0051289 |
protein homotetramerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.