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Overview

Uniprot IDA0A481CKZ1
Protein NamePeriodic tryptophan protein 2 homolog
Gene NamePWP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
258 EERAVRGKAAPAAEE
43 RVTVFDLKNNKSDTL
594 SGRKELDKITAKHSA

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MKFAYRFSNL 20 LGTVYRCGNL 30 NFTCDGNSLI 40 SPVGNRVTVF 50 DLKNNKSDTL 60 PLATRYNIKC 70 VGLSPDGRLA 80 IIVDEGGDAL 90 LVSLVCRSVL 100 HHFHFKGAVH 110 SVAFSPDGRK 120 FVVTKGNGAQ 130 LYHAPGRRRE 140 FNAFVLDKTY 150 FGPYDETTCI 160 DWTDDSKCFV 170 VGSKDMSTWV 180 FGAERWDNLI 190 YYALGGHRDA 200 IVACFFEADS 210 LDVYTLSQDG 220 ALCVWQCDTP 230 PAGLRLKAPS 240 GWRADLQRRE 250 GDEDEEDNEE 260 EERAVRGKAA 270 PAAEEQQGKV 280 RYSRLAKYFF 290 NKEGDFNNLT 300 AAAYHKKVHL 310 LVTGFASGMF 320 HLHELPEFNL 330 IHSLSISDQR 340 VASVAINSSG 350 DWIAFGCSGL 360 GQLLVWEWQS 370 ESYVLKQQGH 380 FNSMVSLAYS 390 PDGQYIVTGG 400 DDGKVKVWNT 410 LSGFCFITFT 420 EHSSGVTGVT 430 FTATGYVIVT 440 SSMDGTVRAF 450 DLHRYRNFRT 460 FTSPRPTQFS 470 CVAVDTSGEV 480 VAAGAQDSFE 490 IFIWSMQTGR 500 LLDVLSGHEG 510 PISGLCFNPT 520 KSVLASASWD 530 RTVRLWDMAD 540 SWRTTETLAL 550 TSDALAVTFR 560 PDGAELAVAT 570 LNSQITFWDP 580 ENAVQTGSIE 590 GRHDLKSGRK 600 ELDKITAKHS 610 AKGKAFTALC 620 YSADGQSVLA 630 GGRSKFVCIY 640 HVREQILRKR 650 FEISGNLSLD 660 AMEEFLNRRK 670 MTEFGNLALI 680 DQDAAEEAGV 690 AIPLPGVKKG 700 DMSSRHFKPE 710 IRVTSLRFSP 720 TGRCWAATTT 730 EGLLIYSLDA 740 RMLFDPFELD 750 TSVTPARVRA 760 ALRQRDFTRA 770 ILMAFRLNER 780 KLLQEALESV 790 PWDEVEVVSS 800 SLPDLYVEKV 810 LEFLASSLEV 820 SHHLEFYLVW 830 AQKLLMAHGQ 840 KLKARAGTLL 850 PAVQFLQKSI 860 QRHFDGLSKL 870 CDWNRYSLRF 880 ALAVSQQRGL 890 KRASEAPGSE 900 EEADGSDEDD 910 ESLHLLGAGP GDADGLRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
Cellular Component GO:0032040 small-subunit processome
Biological Process GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000028 ribosomal small subunit assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.