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Overview

Uniprot IDA0A4X0W8E9
Protein NameActive breakpoint cluster region-related protein
Gene NameAbr
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
594 SFGYFVSKAKTRVFR

Function

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity

Protein Sequence

10 MSLPGAGRGS 20 TSPSGGARDS 30 CACRTGIRPV 40 TARLREAVTA 50 ATTAQTTKTA 60 SPQTSATVQR 70 TTTQRGMRSR 80 RGPPRARRPC 90 HTSTSHPPCR 100 PSSALAARAV 110 GRASHPPHLR 120 GWHLGTPNRV 130 IQWRVNIVIL 140 VQVQRHENQV 150 EAGKGLEMRK 160 LVLSGFLASE 170 EIYINQLEAL 180 LLPMKPLKAT 190 ATTSQPVLTI 200 QQIETIFYKI 210 QDIYEIHKEF 220 YDNLCPKVQQ 230 WDSQVTMGHL 240 FQKLASQLGV 250 YKAFVDNYKV 260 ALETAEKCSQ 270 SNNQFQKISE 280 ELKVKGPKDS 290 KDSHTSVTME 300 ALLYKPIDRV 310 TRSTLVLHDL 320 LKHTPVDHPD 330 YPLLQDALRI 340 SQNFLSSINE 350 DIDPRRTAVT 360 TPKGETRQLV 370 KDGFLVEMSE 380 SSRKLRHVFL 390 FTDVLLCAKL 400 KKTSAGKHQQ 410 YDCKWYIPLA 420 DLVFPSPEES 430 EASPQVHPFP 440 DHELEDMKVK 450 ISALKSEIQK 460 EKANKGQSRA 470 IERLKKKMFE 480 NEFLLLLNSP 490 TIPFRIHNRN 500 GKSYLFLLSS 510 DYERSEWREA 520 IQKLQKKDLQ 530 AFVLSSVELQ 540 VLTGSCFKLR 550 TVHNIPVTSN 560 KDDDESPGLY 570 GFLHVIVHSA 580 KGFKQSANLY 590 CTLEVDSFGY 600 FVSKAKTRVF 610 RDTTEPKWDE 620 EFEIELEGSQ 630 SLRILCYEKC 640 YDKTKVNKDN 650 NEIVDKIMGK 660 GQIQLDPQTV 670 ESKNWHTDVI 680 EMNGIKVEFS 690 MKFTSRDMSL 700 KRTPSKKQTG 710 VFGVKISVVT 720 KRERSKVPYI 730 VRQCIEEVEK 740 RGIEEVGIYR 750 ISGVATDIQA 760 LKAVFDANNK 770 DILLMLSDMD 780 INAIAGTLKL 790 YFRELPEPLL 800 TDRLYPAFME 810 GIALSDPAAK 820 ENCMMHLLRS 830 LPDPNLITFL 840 FLLEHLKRVA 850 EKEPINKMSL 860 HNLATVFGPT 870 LLRPSEVESK 880 AHLTSAADIW 890 SHDVMAQVQV 900 LLYYLQHPPI 910 SFAELKRNTL YFSTDV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0043197 dendritic spine
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0035556 intracellular signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.