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Overview

Uniprot IDA0A4X1SE16
Protein NameCell surface glycoprotein MUC18
Gene NameMCAM
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
119 RIFLCQGKRPRSQEH

Function

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration

Protein Sequence

10 MGTSGLICAF 20 LLASCCCCRR 30 VAGVPGEAEK 40 PAPELLEVEV 50 GGTALLKCGP 60 SHSQSNFSHV 70 DWFSVHKEKP 80 TLIFRVRQGQ 90 GQSEPGEYQH 100 RLHLQDKGTT 110 LALTHITPHD 120 ERIFLCQGKR 130 PRSQEHRVQL 140 RVYKAPEEPT 150 IQVNPLGISV 160 NSEEPEEVAT 170 CVGRNGYPLP 180 QVIWYKNGRP 190 LKEEKNRVQI 200 QSFQIVESSG 210 LYTLQSVLKA 220 QLAKEDKDAQ 230 FYCELSYRLP 240 SGNHMKESPE 250 VMVPVFYPAE 260 RVWLEVEPEG 270 MLKEGDRVEI 280 RCLADGNPPP 290 HFSISKQNLS 300 TKEMEEESTD 310 DNGILVLEPA 320 QKEHSGLYEC 330 QGLDLETTVS 340 LLSDQQELLV 350 NYVSDVRVSP 360 AAPESQEGSS 370 LTLTCEAESN 380 QDLEFQWLRE 390 KTGKVLERGP 400 VLQLRNLKRE 410 EGGGYRCVAS 420 APSVPGLNRT 430 QLVNVAIFGS 440 PWMTLRERKI 450 RVKENTMLNL 460 SCEASGHPRP 470 SIIWNVDGTA 480 SEQDQDPQTV 490 LSILSVLVTP 500 ELLETGAKCV 510 ASNPLGENVT 520 SIILELDSNR 530 TNSLSTSTFS 540 PPARANSTST 550 ERKLPEPESK 560 GVVIVAVTVC 570 VLVLAVLGAV 580 LYFFYKKGKL 590 PCGRSGKQEM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Biological Process GO:0007155 cell adhesion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.