Overview
| Uniprot ID | A0A4X1SHD5 |
|---|
| Protein Name | Very-long-chain 3-oxoacyl-CoA reductase |
|---|
| Gene Name | HSD17B12 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 72 |
SYAEELAKRGMKIVL |
Function
Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation
Protein Sequence
10
METALPAAGF
20
LYWVGASTVA
30
YLALRISCWF
40
FTALRVWGLG
50
HEAGVGPWLG
60
EWAVVTGGTD
70
GIGKSYAEEL
80
AKRGMKIVLI
90
SRSQDKLDQV
100
SSEIMNNVGM
110
SYEYPEYFLD
120
VPDLDNTIKK
130
LITVNALSVC
140
KMTRLVLPGM
150
VERSKGAILN
160
ISSASGMYPV
170
PLLTIYSATK
180
AFVDFFSQCL
190
HEEYKSKGVI
200
VQSVLPYYVA
210
TKLAKIKRPT
220
WDKPSPETFV
230
KSAMKTIGVQ
240
SRTNGYPIHS
250
LVASVSASLP
260
SWLYFKIAMY
270
SGNSIRVRYL
KKMKMN
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0004303 |
estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| Molecular Function |
GO:0141040 |
very-long-chain 3-oxoacyl-CoA reductase activity |
| Biological Process |
GO:0006694 |
steroid biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.