Search Results
Overview
| Uniprot ID | A0A4X1SHF6 |
|---|---|
| Protein Name | Porphobilinogen deaminase |
| Gene Name | HMBS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 52 | ILDTALSKIGEKSLF |
Function
As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact
Protein Sequence
10
MSGNGNAAAT
20
ALARIQTDSV
30
VATLKALYPG
40
LQFEIIAMST
50
TGDKILDTAL
60
SKIGEKSLFT
70
KELEHALERN
80
EVDLVVHSLK
90
DLPTVLPPGF
100
TIGAVCKREC
110
PYDAVVFHPK
120
FVGKTLETLP
130
EKSVVGTSSL
140
RRAAQLQRKF
150
PHLEFKSIRG
160
NLNTRLRKLD
170
ELQEFSAIIL
180
AAAGLQRMGW
190
QNRVGQGALG
200
VEVRAKDQDI
210
LDLVGVLHDP
220
ETLLRCIAER
230
AFLRHLEGGC
240
SVPVAVHTAM
250
KDGQLYLTGG
260
VWSLNGAESM
270
QETMQATIHV
280
PAQHEDGPED
290
DPQLVGITAR
300
NIPREAQLAA
310
ENLGISLATL
320
LLNKGAKNIL
330
DVARQLNDAH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004418 | hydroxymethylbilane synthase activity |
| Biological Process | GO:0006782 | protoporphyrinogen IX biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.