Search Results
Overview
| Uniprot ID | A0A4X1SI63 |
|---|---|
| Protein Name | Peroxiredoxin-like 2A |
| Gene Name | PRXL2A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 118 | AVVKEQVKNEVKDFQ |
| 138 | EIFLDEEKKFYGPQR |
| 201 | ILLEHREKEFGDKVN |
| 67 | EPKTFKAKALWEKTG |
| 99 | AADLSSLKPRLDELG |
Function
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway
Protein Sequence
10
MSFLQDPSFV
20
TMGMWSIGAG
30
AIGAAALALL
40
LANTDIFLPK
50
PQRATLDYLE
60
DIDLKTLEKE
70
PKTFKAKALW
80
EKTGAVIMAV
90
RRPGCFLCRE
100
EAADLSSLKP
110
RLDELGVPLY
120
AVVKEQVKNE
130
VKDFQPYFKG
140
EIFLDEEKKF
150
YGPQRRKMMF
160
MGFVRLGVWY
170
NFFRARSGGF
180
SGNLEGEGFV
190
LGGVFVVGPG
200
KQGILLEHRE
210
KEFGDKVNPV
220
SVLEAVRKIK
PHTSASEKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0016209 | antioxidant activity |
| Biological Process | GO:0045670 | regulation of osteoclast differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.