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Overview

Uniprot IDA0A4X1SJ12
Protein NameNucleolar protein 56
Gene NameNOP56
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
134 LHFHNLVKGLTDLSA
158 SYSRAKVKFNVNRVD
227 RRELNEEKLEKLEEL
242 TMDGAKAKAILDASR
375 ISRYLANKCSIASRI
537 GSLPKRKKSLSSPVS
87 LETHLPSKKKKVLLG
90 HLPSKKKKVLLGVGD

Function

Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)

Protein Sequence

10 MVLLHVLFEH 20 AVGYALLALK 30 EVEEISLLLP 40 QVEECVLNLG 50 KFHNIVRLVA 60 FSPFSSSQVA 70 LENANAVSEG 80 VVHEDLRLFL 90 ETHLPSKKKK 100 VLLGVGDPKI 110 GAAIQEELGY 120 NCQTGGVIAE 130 VLRGVRLHFH 140 NLVKGLTDLS 150 ACKAQLGLGH 160 SYSRAKVKFN 170 VNRVDNMIIQ 180 SISLLDQLDK 190 DINTFSMRVR 200 EWYGYHFPEL 210 VKIINDNATY 220 CRLAQFIGNR 230 RELNEEKLEK 240 LEELTMDGAK 250 AKAILDASRS 260 SMGMDISAID 270 LINIESFSSR 280 VVSLSEYRQS 290 LHTYLRSKMS 300 QVAPSLSALI 310 GEAVGARLIA 320 HAGSLTNLAK 330 YPASTVQILG 340 AEKALFRALK 350 TRGNTPKYGL 360 IFHSTFIGRA 370 AAKNKGRISR 380 YLANKCSIAS 390 RIDCFSEVPT 400 SVFGEKLREQ 410 VEERLSFYET 420 GEIPRKNLEV 430 MKEAMVQAEE 440 AAAEITRKLE 450 KQEKKRLKKE 460 KKRLAAVALA 470 SSENSSSTPE 480 ECEETSERPK 490 KKKKKQKPQE 500 VPQENGMEDP 510 PVSFSKPKKK 520 KAFSKEELVS 530 SDLEERAGSG 540 SLPKRKKSLS 550 SPVSDPEESG 560 NKKIPKKKRK 570 LSPKEEPLSS 580 GPEEAAVSKS 590 SGSKKKKKLQ KLSQET

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031428 box C/D methylation guide snoRNP complex
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0070761 pre-snoRNP complex
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:1990226 histone methyltransferase binding
Molecular Function GO:0030515 snoRNA binding
Biological Process GO:0042274 ribosomal small subunit biogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.