Overview
| Uniprot ID | A0A4X1SLP6 |
|---|
| Protein Name | COP9 signalosome complex subunit 2 |
|---|
| Gene Name | COPS2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 139 |
DDGEDDLKKGTQLLE |
| 165 |
QKNNKKLKALYEQSL |
| 43 |
PEMMNRYKQLLTYIR |
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1
Protein Sequence
10
MVISYKVLEL
20
EGEKGEWGFK
30
ALKQMIKINF
40
KLTNFPEMMN
50
RYKQLLTYIR
60
SAVTRNYSEK
70
SINSILDYIS
80
TSKQMDLLQE
90
FYETTLEALK
100
DAKNDRLWFK
110
TNTKLGKLYL
120
EREEYGKLQK
130
ILRQLHQSCQ
140
TDDGEDDLKK
150
GTQLLEIYAL
160
EIQMYTAQKN
170
NKKLKALYEQ
180
SLHIKSAIPH
190
PLIMGVIREC
200
GGKMHLREGE
210
FEKAHTDFFE
220
AFKNYDESGS
230
PRRTTCLKYL
240
VLANMLMKSG
250
INPFDSQEAK
260
PYKNDPEILA
270
MTNLVSAYQN
280
NDITEFEKIL
290
KTNHSNIMDD
300
PFIREHIEEL
310
LRNIRTQVLI
320
KLIKPYTRIH
330
IPFISKELNI
340
DVADVESLLV
350
QCILDNTIHG
360
RIDQVNQLLE
370
LDHQKRGGAR
380
YTALDKWTNQ
390
LNSLNQAVVS
KLA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.