Overview
| Uniprot ID | A0A4X1SN00 |
|---|
| Protein Name | COP9 signalosome complex subunit 2 |
|---|
| Gene Name | COPS2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 125 |
DDGEDDLKKGTQLLE |
| 151 |
QKNNKKLKALYEQSL |
| 29 |
PEMMNRYKQLLTYIR |
Function
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1
Protein Sequence
10
MSDMEDDFMC
20
DDEEDYDLTN
30
FPEMMNRYKQ
40
LLTYIRSAVT
50
RNYSEKSINS
60
ILDYISTSKQ
70
MDLLQEFYET
80
TLEALKDAKN
90
DRLWFKTNTK
100
LGKLYLEREE
110
YGKLQKILRQ
120
LHQSCQTDDG
130
EDDLKKGTQL
140
LEIYALEIQM
150
YTAQKNNKKL
160
KALYEQSLHI
170
KSAIPHPLIM
180
GVIRECGGKM
190
HLREGEFEKA
200
HTDFFEAFKN
210
YDESGSPRRT
220
TCLKYLVLAN
230
MLMKSGINPF
240
DSQEAKPYKN
250
DPEILAMTNL
260
VSAYQNNDIT
270
EFEKILKTNH
280
SNIMDDPFIR
290
EHIEELLRNI
300
RTQVLIKLIK
310
PYTRIHIPFI
320
SKELNIDVAD
330
VESLLVQCIL
340
DNTIHGRIDQ
350
VNQLLELDHQ
360
KRGGARYTAL
370
DKWTNQLNSL
NQAVVSKLA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.