Overview
| Uniprot ID | A0A4X1SPQ9 |
|---|
| Protein Name | Beta-hexosaminidase |
|---|
| Gene Name | HEXB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 352 |
NMISAMKKRPIVWQE |
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida
Protein Sequence
10
MAMERHGWRW
20
LPGLLALLAA
30
LVVPKGWARD
40
TSGAESLGLW
50
PLPFAVDISP
60
RSLHLSPNNF
70
FFGHSPTSKA
80
GSSCEILQEA
90
FRRYYDFIFG
100
FYKWHQGSYQ
110
LCFGTELQQL
120
QVHVESECDT
130
FPSISSNESY
140
VLHVKGPEAL
150
LRANTVWGAL
160
RGLETFSQLI
170
YQDSYGTFTV
180
NESEIIDFPR
190
FPHRGILIDT
200
GRHFLSVKTI
210
FKTLDAMAFN
220
KFNVLHWHIV
230
DDQSFPYQSI
240
NFPLLSSKGS
250
YSLSHVYTPN
260
DVRMVIEYAR
270
IRGIRVMPEF
280
DTPGHSRSWG
290
KGQKDLLTPC
300
YRKQVLSGTF
310
GPINPILNTT
320
YNFLSKFFKE
330
ISTVFPDEFI
340
HIGGDEVDFD
350
CWISNMISAM
360
KKRPIVWQEA
370
FDGRDKFMPG
380
TVVQVWKIED
390
YKWEQSLITK
400
AGFPVILSAP
410
WYLDLISYGQ
420
DWKNYYEVEP
430
QDFPGSDKER
440
KRVLGGEACL
450
WGEYVDATNL
460
TPRLWPRASA
470
VGERLWSHKD
480
VRDIHDAYSR
490
LTIHRCRMVR
500
RGIAAEPLFT
GYCNHEHRM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0060473 |
cortical granule |
| Cellular Component |
GO:0005764 |
lysosome |
| Molecular Function |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
| Biological Process |
GO:1901135 |
carbohydrate derivative metabolic process |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.