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Overview

Uniprot IDA0A4X1SQ46
Protein NamecAMP-dependent protein kinase type I-alpha regulatory subunit
Gene NamePRKAR1A
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
221 VKAKTNVKLWGIDRD
23 ECELYVQKHNIQALL
366 GPCSDILKRNIQQYN

Function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells

Protein Sequence

10 MASGSTASEE 20 ERSLRECELY 30 VQKHNIQALL 40 KDSIVQLCTA 50 RPERPMAFLR 60 EYFERLEKEE 70 AKQIQNLQKA 80 SARADSREDE 90 ISPPPPNPVV 100 KGRRRRGAIS 110 AEVYTEEDAA 120 SYVRKVIPKD 130 YKTMAALAKA 140 IEKNVLFSHL 150 DDNERSDIFD 160 AMFPVSFIAG 170 ETVIQQGDEG 180 DNFYVIDQGE 190 MDVYVNNEWA 200 TSVGEGGSFG 210 ELALIYGTPR 220 AATVKAKTNV 230 KLWGIDRDSY 240 RRILMGSTLR 250 KRKMYEEFLS 260 KVSILESLDK 270 WERLTVADAL 280 EPVQFEDGQK 290 IVVQGEPGDE 300 FFIILEGSAA 310 VLQRRSENEE 320 FVEVGRLGPS 330 DYFGEIALLM 340 NRPRAATVVA 350 RGPLKCVKLD 360 RPRFERVLGP 370 CSDILKRNIQ 380 QYNSFVSLSV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005930 axoneme
Cellular Component GO:0005952 cAMP-dependent protein kinase complex
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0001772 immunological synapse
Cellular Component GO:0005771 multivesicular body
Cellular Component GO:0031594 neuromuscular junction
Cellular Component GO:0031588 nucleotide-activated protein kinase complex
Cellular Component GO:0044853 plasma membrane raft
Cellular Component GO:0120212 sperm head-tail coupling apparatus
Molecular Function GO:0030552 cAMP binding
Molecular Function GO:0004862 cAMP-dependent protein kinase inhibitor activity
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0034236 protein kinase A catalytic subunit binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0071377 cellular response to glucagon stimulus
Biological Process GO:0046007 negative regulation of activated T cell proliferation
Biological Process GO:0141162 negative regulation of cAMP/PKA signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.