Search Results
Overview
| Uniprot ID | A0A4X1SRJ2 |
|---|---|
| Protein Name | GMP reductase |
| Gene Name | GMPR2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 249 | SSEMAMKKYAGGVAE |
| 270 | KTVEVPFKGAVEHTI |
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors
Protein Sequence
10
MPHIDNDVKL
20
DFKDVLLRPK
30
RSTLKSRSEV
40
DLTRSFSFRN
50
SKQMYTGIPI
60
IAANMDTVGT
70
FEMAKVLCKH
80
LAASSGTGSS
90
DFEQLEQILD
100
AIPQVKYICL
110
DVANGYSEHF
120
VEFVKDVRKR
130
FPEHTIMAGN
140
VVTGEMVEEL
150
ILSGADIIKV
160
GIGPGSVCTT
170
RKKTGVGYPQ
180
LSAVMECADA
190
AHGLKGHIIS
200
DGGCSCPGDV
210
AKAFGAGADF
220
VMLGGMLAGH
230
SESGGELIER
240
NGKKYKLFYG
250
MSSEMAMKKY
260
AGGVAEYRAS
270
EGKTVEVPFK
280
GAVEHTIRDI
290
LGGIRSTCTY
300
VGAAKLKELS
310
RRTTFIRVTQ
320
QVNPIFSDES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1902560 | GMP reductase complex |
| Molecular Function | GO:0003920 | GMP reductase activity |
| Molecular Function | GO:0003938 | IMP dehydrogenase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006177 | GMP biosynthetic process |
| Biological Process | GO:0006144 | purine nucleobase metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.