Search Results

Overview

Uniprot IDA0A4X1STM2
Protein NameNAD(P) transhydrogenase, mitochondrial
Gene NameNNT
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1098 MLLGDAKKTCDALQA
1106 TCDALQAKVRESYQK
351 TALIPGKKAPVLFNK
478 IPQGAPVKQKTVAEL
97 KEIFQNEKRVALSPA

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland

Protein Sequence

10 MTQEVASEIL 20 TYLQGNWAFG 30 KLGAPRNMAN 40 LLKTVVTGCS 50 CPFRSSWGSC 60 KVLPGKKDFL 70 RTFHTHQALW 80 CKAPVKPGIP 90 YKQLTVGVPK 100 EIFQNEKRVA 110 LSPAGVQALV 120 KQGFNVVVES 130 GAGEASKFSD 140 DHYRAAGAQI 150 QGVKEVLASD 160 LVVKVRAPML 170 NPTLGVHEAD 180 LLKTSATLIS 190 FIYPAQNPDL 200 LNKLSKRKTT 210 VLAMDQVPRV 220 TIAQGYDALS 230 SMANIAGYKA 240 VVLAANHFGR 250 FFTGQITAAG 260 KVPPAKILIV 270 GGGVAGLASA 280 GAAKSMGAIV 290 RGFDTRAAAL 300 EQFKSLGAEP 310 LEVDLKESGE 320 GQGGYAKEMS 330 KEFIEAEMKL 340 FAQQCKEVDI 350 LISTALIPGK 360 KAPVLFNKEM 370 IESMKEGSVV 380 VDLAAEAGGN 390 FETTKPGELY 400 VHKGVTHIGY 410 TDLPSRMATQ 420 ASTLYSNNIT 430 KLLKAISPDK 440 DNFYFEVKDD 450 FDFGTMGHVI 460 RGTVVMKDGE 470 VIFPAPTPKN 480 IPQGAPVKQK 490 TVAELEAEKA 500 ATITPFRKTM 510 TSASVYTAGL 520 TGILGLGLAA 530 PNLAFSQMVT 540 TFGLAGIVGY 550 HTVWGVTPAL 560 HSPLMSVTNA 570 ISGLTAVGGL 580 VLMGGHLYPS 590 TTSQGLAALA 600 TFISSVNIAG 610 GFLVTQRMLD 620 MFKRPTDPPE 630 YNYLYLLPAG 640 TFVGGYLAAL 650 YSGYNIEQIM 660 YLGSGLCCVG 670 ALAGLSTQGT 680 ARLGNALGMI 690 GVAGGLAATL 700 GGLKPCPELL 710 AQMSGAMALG 720 GTIGLTIAKR 730 IQISDLPQLV 740 AAFHSLVGLA 750 AVLTCIAEYI 760 VEYPHFATDA 770 AANLTKIVAY 780 LGTYIGGVTF 790 SGSLIAYGKL 800 QGILKSAPLL 810 LPGRHLLNAG 820 LLAASVGGII 830 PFMVDPSFTT 840 GITCLGSVSA 850 LSAVMGVTLT 860 AAIGGADMPV 870 VITVLNSYSG 880 WALCAEGFLL 890 NNNLLTIVGA 900 LIGSSGAILS 910 YIMCVAMNRS 920 LANVILGGYG 930 TTSTAGGKPM 940 EISGTHTEIN 950 LDNAIDMIRE 960 ANSIIITPGY 970 GLCAAKAQYP 980 IADLVKMLSE 990 QGKKVRFGIH 1000 PVAGRMPGQL 1010 NVLLAEAGVP 1020 YDIVLEMDEI 1030 NHDFPDTDLV 1040 LVIGANDTVN 1050 SAAQEDPNSI 1060 IAGMPVLEVW 1070 KSKQVIVMKR 1080 SLGVGYAAVD 1090 NPIFYKPNTA 1100 MLLGDAKKTC 1110 DALQAKVRES YQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0050661 NADP binding
Molecular Function GO:0016491 oxidoreductase activity
Molecular Function GO:0008750 proton-translocating NAD(P)+ transhydrogenase activity
Biological Process GO:0006740 NADPH regeneration
Biological Process GO:0072593 reactive oxygen species metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.