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Overview

Uniprot IDA0A4X1SU61
Protein NameMelanoma inhibitory activity protein 2
Gene NameMIA2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
861 VEQVLCDKENQIKSL

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites

Protein Sequence

10 MAELGIHRIL 20 LLVISLTKCL 30 EGTKRLADFK 40 KCGDLECETL 50 ISRVLAIRDY 60 RGPDCRYLNF 70 TKGEEISVYI 80 KLAGEKEDLW 90 AGSKGKDFGY 100 FPRDAVQIEE 110 VFISEEVQIS 120 TKESDFFCLL 130 GISYTFENED 140 IELNIDHSDN 150 IYLYEEDEDP 160 KSNVYESDFQ 170 IEPGFFSTSE 180 GTLFEDQFPA 190 SEAPEAIRST 200 SESKDWEAAE 210 VRSVEEHPLP 220 EVDHVPPSSA 230 VPEVKGWFGF 240 RKDQAEGETF 250 ESVIEPLQES 260 SLLSRKIAVE 270 DENDPEKLNN 280 DEPQTEHKQE 290 PESEVDSMPT 300 KQSELVSESE 310 HYPQDTGWFG 320 GRFTSYFGFR 330 GEDTGLELLS 340 KESNPPLQDV 350 PNSISSEEES 360 TVPCTETLTE 370 KEDTLTNDSS 380 ILKPRWFEFG 390 FAMLGIAYAN 400 EDKIISDDGK 410 NEESGGEDKH 420 GPPPTSEFDP 430 GEEQELKIMK 440 IVETESQIGK 450 EGALEKTDDS 460 DTLPYFKKFL 470 GNFENSWNFK 480 NIPKETELPF 490 PKKTLDENNV 500 GENDETEEFS 510 LENYPTDNTE 520 DMTLESRYSQ 530 SDMNSKIELP 540 MIIHEEVHFK 550 TLSSENNDEN 560 SKTSLDTERS 570 TMVEIDTSVE 580 NTLPNSQIFS 590 TDYSLSSQNY 600 LDQKEDASVG 610 QILKYLFQID 620 VFDFLNPAFS 630 PIVILTGRVV 640 AALPEDMNFH 650 GFPWEVVICA 660 TIVGLFAVVL 670 FLWRSFRSVR 680 SRLYVGREKK 690 LAAELSALIE 700 EKCKLLEKFS 710 LVQKEYEGLE 720 SSLKDASFEK 730 ESTEAQSLEA 740 FCGKLINSQS 750 ELEDEILFLE 760 KELREEKSKH 770 SEQDELMVDI 780 SKRIQSLEDE 790 SKSLKSQVSE 800 AKTTFKIFQM 810 NEERLKISIK 820 DALSENSQLQ 830 ESQKQLLQEA 840 EEWRERVNEL 850 NKQKMTFEDS 860 RAHVEQVLCD 870 KENQIKSLTE 880 RLLKMKDWSA 890 VLGEDITNDD 900 NLDLEMKNDS 910 ENDTLPKGTL 920 KKLIHAAKLK 930 ASLKTLEGER 940 NQIYTQLSEV 950 DKTKEDLTEC 960 IENLQTEQAS 970 LQSENTQFEN 980 EIQKLQQKLK 990 VMTELYQENE 1000 MTLHRKLTVE 1010 ENYRLEKEEK 1020 LSKADEKISH 1030 AVEELETYRK 1040 RARDLEEELE 1050 RTIHSYQGQS 1060 ISHEKKAHDN 1070 WLAARNAERN 1080 LNDLRKENAY 1090 SRQKLTETEL 1100 KFELLEKDPY 1110 ALDVPNTAFG 1120 RGSRGPGNPL 1130 DHPITNERGD 1140 SSADWLIDPH 1150 RAPSDTGSLS 1160 PPWEQDRRMM 1170 IPPSGQPYPD 1180 PVFPPQRQDR 1190 FYSNSGRLSG 1200 PAELRSFNMP 1210 SLDKVDGPVS 1220 SEMESNRTDG 1230 KDDLGNLNVP 1240 DSSLPNESEA 1250 TGPGFVPPPR 1260 PPVRGPLFPL 1270 DARGPFLRRG 1280 PPFPPPPPGS 1290 MYAAPRDYFP 1300 PRDFPGPPPP 1310 PFAMRSVYPP 1320 RGFPHYLPPR 1330 AGFFPPPPHP 1340 ESRSEFPAGL 1350 IPPSNEPTTE HPEPQQET

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.