Search Results
Overview
| Uniprot ID | A0A4X1SWC8 |
|---|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 12 |
| Gene Name | PSMD12 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | IERARLTKTLATIKE |
| 207 | IRTQIISKKINTKFF |
| 212 | ISKKINTKFFQEENT |
| 221 | FQEENTEKLKLKYYN |
| 405 | VNKTIFAKVDRLAGI |
| 98 | SKRRSQLKQAVAKMV |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair
Protein Sequence
10
MADGGSERAD
20
GRIVKMEVDY
30
SATVDQRLPE
40
CEKLAKEGRL
50
QEVIETLLSL
60
EKQTRTASDM
70
VSTSRILVAV
80
VKMCYEAKEW
90
DLLNENIMLL
100
SKRRSQLKQA
110
VAKMVQQCCT
120
YVEEITDLPV
130
KLRLIDTLRM
140
VTEGKIYVEI
150
ERARLTKTLA
160
TIKEQNGDVK
170
EAASILQELQ
180
VETYGSMEKK
190
ERVEFILEQM
200
RLCLAVKDYI
210
RTQIISKKIN
220
TKFFQEENTE
230
KLKLKYYNLM
240
IQLDQHEGSY
250
LSICKHYRAI
260
YDTPCIQAES
270
EKWQQALKSV
280
VLYVILAPFD
290
NEQSDLVHRI
300
SGDKKLEEIP
310
KYKDLLKLFT
320
TMELMRWSTL
330
VEDYGMELRK
340
GSLESPATDV
350
FGYTEEGEKR
360
WKDLKNRVVE
370
HNIRIMAKYY
380
TRITMKRMAQ
390
LLDLSVDESE
400
AFLSNLVVNK
410
TIFAKVDRLA
420
GIINFQRPKD
430
PNNLLNDWSQ
440
KLNSLMSLVN
450
KTTHLIAKEE
MIHNLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0008541 | proteasome regulatory particle, lid subcomplex |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.