Overview
| Uniprot ID | A0A4X1SXY5 |
|---|
| Protein Name | V-type proton ATPase catalytic subunit A |
|---|
| Gene Name | ATP6V1A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 221 |
QVRPVTEKLPANHPL |
Function
Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity
Protein Sequence
10
MMDFSKLPKI
20
LDEDKESTFG
30
YVHGVSGPVV
40
TACDMAGAAM
50
YELVRVGHSE
60
LVGEIIRLEG
70
DMATIQVYEE
80
TSGVSVGDPV
90
LRTGKPLSVE
100
LGPGIMGAIF
110
DGIQRPLSDI
120
SSQTQSIYIP
130
RGVNVSALSR
140
DVKWEFTPSK
150
NLRVGSHITG
160
GDIYGIVNEN
170
SLIKHRIMLP
180
PRNRGTVTYI
190
APPGNYDTSD
200
VVLELEFEGV
210
KEKFSMVQVW
220
PVRQVRPVTE
230
KLPANHPLLT
240
GQRVLDALFP
250
CVQGGTTAIP
260
GAFGCGKTVI
270
SQSLSKYSNS
280
DVIIYVGCGE
290
RGNEMSEVLR
300
DFPELTMEVD
310
GKVESIMKRT
320
ALVANTSNMP
330
VAAREASIYT
340
GITLSEYFRD
350
MGYHVSMMAD
360
STSRWAEALR
370
EISGRLAEMP
380
ADSGYPAYLG
390
ARLASFYERA
400
GRVKCLGNPE
410
REGSVSIVGA
420
VSPPGGDFSD
430
PVTSATLGIV
440
QVFWGLDKKL
450
AQRKHFPSVN
460
WLISYSKYMR
470
ALDEYYDKHF
480
TEFVPLRTKA
490
KEILQEEEDL
500
AEIVQLVGKA
510
SLAETDKITL
520
EVAKLIKDDF
530
LQQNGYTPYD
540
RFCPFYKTVG
550
MLSNMIAFYD
560
MARRAVETTA
570
QSDNKITWSI
580
IREHMGEILY
590
KLSSMKFKDP
600
VKDGEAKIKA
610
DYAQLLEDMQ
NAFRSLED
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0030665 |
clathrin-coated vesicle membrane |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0046612 |
lysosomal proton-transporting V-type ATPase, V1 domain |
| Cellular Component |
GO:0005902 |
microvillus |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0030141 |
secretory granule |
| Cellular Component |
GO:0030133 |
transport vesicle |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:0046034 |
ATP metabolic process |
| Biological Process |
GO:0036295 |
cellular response to increased oxygen levels |
| Biological Process |
GO:0006879 |
intracellular iron ion homeostasis |
| Biological Process |
GO:1902600 |
proton transmembrane transport |
| Biological Process |
GO:0097401 |
synaptic vesicle lumen acidification |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.