Overview
| Uniprot ID | A0A4X1SYQ6 |
|---|
| Protein Name | Platelet-activating factor acetylhydrolase IB subunit alpha2 |
|---|
| Gene Name | PAFAH1B2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 125 |
PLRQKNAKVNQLLKV |
| 131 |
AKVNQLLKVSLPKLA |
Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis
Protein Sequence
10
MSQGDSNPAA
20
IPHAAEDIQG
30
DDRWMSQIWR
40
ELFSPLHALN
50
FGIGGDTTRH
60
VLWRLKNGEL
70
ENIKPKVIVV
80
WVGTNNHENT
90
AEEVAGGIEA
100
IVQLINTRQP
110
QAKIIVLGLL
120
PRGEKPNPLR
130
QKNAKVNQLL
140
KVSLPKLANV
150
QLLDTDGGFV
160
HSDGAISCHD
170
MFDFLHLTGG
180
GYAKICKPLH
190
ELIMQLLEET
PEEKQTTIA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0003847 |
1-alkyl-2-acetylglycerophosphocholine esterase activity |
| Biological Process |
GO:0016042 |
lipid catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.