Overview
| Uniprot ID | A0A4X1SZM2 |
|---|
| Protein Name | Galactose mutarotase |
|---|
| Gene Name | GALM |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 106 |
CLKRSKEKQFCARVH |
| 145 |
LDGTLKGKTGAVYPK |
Function
Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose
Protein Sequence
10
MVSVTRSVFG
20
DLPSGAGTVE
30
KFQLQSDQLR
40
VDIISWGCTI
50
TALEVKDRQG
60
RASDVVLGFA
70
ELKGEIAPVQ
80
GTAFDLRKPV
90
ELGKHLQEFH
100
INGFDHNFCL
110
KRSKEKQFCA
120
RVHHAGSGRV
130
LEVYTTQPGI
140
QFYTGNFLDG
150
TLKGKTGAVY
160
PKHSGFCLET
170
QNWPNAVNQP
180
HFPPVLLKPG
190
EEYNHTTWFV
FSVA
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0004034 |
aldose 1-epimerase activity |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Biological Process |
GO:0006012 |
galactose metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.