Search Results
Overview
| Uniprot ID | A0A4X1T454 |
|---|---|
| Protein Name | SRA stem-loop-interacting RNA-binding protein, mitochondrial |
| Gene Name | SLIRP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | KLHVQAQKRKALQGD |
| 61 | RPVAFVRKIPWTAAS |
| 83 | AQFGHIRKCIVPFDK |
Function
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation
Protein Sequence
10
MSRPVSSDPE
20
ADFRAPGSDR
30
FFRGRDLKAL
40
GSLNLNMAAS
50
AARGVLSMRA
60
NVGRPVAFVR
70
KIPWTAASNE
80
LREHFAQFGH
90
IRKCIVPFDK
100
ETGFHRGMGW
110
IQFSSEEELH
120
NVLQQENHVI
130
DGVKLHVQAQ
140
KRKALQGDQT
SDEEKDF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0036126 | sperm flagellum |
| Molecular Function | GO:0003729 | mRNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0097222 | mitochondrial mRNA polyadenylation |
| Biological Process | GO:1905638 | negative regulation of mitochondrial mRNA catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.